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Merck
CN

57858

Sodium iodoacetate

BioUltra, ≥99.5% (NT)

Synonym(s):

Iodoacetic acid sodium salt

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About This Item

Linear Formula:
ICH2COONa
CAS Number:
Molecular Weight:
207.93
UNSPSC Code:
12352106
NACRES:
NA.26
PubChem Substance ID:
EC Number:
206-165-7
Beilstein/REAXYS Number:
4009322
MDL number:
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product line

BioUltra

Quality Level

assay

≥99.5% (NT)

impurities

insoluble matter, passes filter test, ≤0.5% water

mp

208 °C (dec.) (lit.)

solubility

methanol: 0.1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤100 mg/kg, sulfate (SO42-): ≤100 mg/kg

cation traces

Al: ≤5 mg/kg, As: ≤0.1 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤500 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg

absorption

cut-off at 335 nm in methanol at 0.1 M

storage temp.

−20°C

SMILES string

[Na+].[O-]C(=O)CI

InChI

1S/C2H3IO2.Na/c3-1-2(4)5;/h1H2,(H,4,5);/q;+1/p-1

InChI key

AGDSCTQQXMDDCV-UHFFFAOYSA-M

Application

Reagent for the modification of cysteine residues in proteins.
Reagent for the modification of cysteine residues in proteins. Used in protein sequencing (including by Sanger in sequencing bovine insulin) to prevent oxidation of -SH sidechains.
Reagent for the modification of cysteine residues in proteins. Used to induce animal osteoarthritis model system, which mimics both symptoms and histopathology of the human disease.

Other Notes

Sulfhydryl reagent


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pictograms

Skull and crossbonesCorrosion

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Corr. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

406.4 °F

flash_point_c

208 °C

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges



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J L Leonard et al.
Biochimica et biophysica acta, 787(2), 122-130 (1984-06-14)
Pretreatment of renal iodothyronine 5'-deiodinase with sulfhydryl reagents, iodoacetate, iodoacetamide and N-alkylmaleimides, results in irreversible loss of catalytic activity. Iodoacetate and iodoacetamide were the most potent inhibitors, being 100- to 1000-times more potent than N-alkylmaleimides. Iodoacetate and iodoacetamide inactivation followed
F.R. Gurd
Methods in Enzymology, 11, 532-532 (1973)
Mohammed Gagaoua et al.
Journal of agricultural and food chemistry, 63(30), 6799-6809 (2015-07-15)
Many studies on color biochemistry and protein biomarkers were undertaken in post-mortem beef muscles after ≥24 hours. The present study was conducted on Longissimus thoracis muscles of 21 Blond d'Aquitaine young bulls to evaluate the relationships between protein biomarkers present



Global Trade Item Number

SKUGTIN
57858-25G-F04061832629230
57858-5G-F04061832629254