70485
Naphthol AS-E phosphate
suitable for histology
Synonym(s):
KG-501
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About This Item
Empirical Formula (Hill Notation):
C17H13ClNO5P
CAS Number:
Molecular Weight:
377.72
UNSPSC Code:
12352204
NACRES:
NA.83
PubChem Substance ID:
EC Number:
242-106-1
Beilstein/REAXYS Number:
6664478
MDL number:
assay
≥80% (HPLC)
Quality Level
form
powder
application(s)
histology
storage temp.
2-8°C
SMILES string
OP(O)(=O)Oc1cc2ccccc2cc1C(=O)Nc3ccc(Cl)cc3
InChI
1S/C17H13ClNO5P/c18-13-5-7-14(8-6-13)19-17(20)15-9-11-3-1-2-4-12(11)10-16(15)24-25(21,22)23/h1-10H,(H,19,20)(H2,21,22,23)
InChI key
RQAQWBFHPMSXKR-UHFFFAOYSA-N
Application
Naphthol AS-E phosphate has been used as a cAMP-response element-binding protein (CREB) inhibitor to dissolve in dimethyl sulfoxide (DMSO) as a stock solution in the study to test the hypothesis that oncostatin M (OSM) may confer neuronal resistance against 3-nitropropionic acid (3-NP).
Biochem/physiol Actions
Naphthol AS-E phosphate/KG501, a small-molecule antagonist has the ability to prevent cAMP-response element-binding protein (CREB) pathway. It can also interfere with the interaction of Myb-KIX in vitro and block the actions of Myb in vivo.
Other Notes
Histochemical substrate for alkaline phosphatases,KG-501 blocks cAMP-induction of CREB (cAMP Response Element Binding Protein)-dependent target gene transcription (Ki 10 microM)) through interference in the binding between the KID domain of CREB and KIX domain of CBP (CREB Binding Protein), classic activator-coactivator interaction.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Naphthol AS-E phosphate inhibits the activity of the transcription factor Myb by blocking the interaction with the KIX domain of the coactivator p300
Uttarkar S, et al.
Molecular Cancer Therapeutics, molcanther-molcan0662 (2015)
Phosphates of the naphthol AS series in the quantitative determination of alkaline and acid phosphatase activities in situ studied in polyacrylamide membrane model systems and by cytospectrophotometry
Lojda, Z., et al.
Histochemistry and Cell Biology, 11, 13-32 (1967)
Kaori Kubota et al.
Frontiers in pharmacology, 8, 850-850 (2017-12-07)
Hachimijiogan (HJG) is a traditional herbal medicine that improves anxiety disorders in patients with dementia. In this study, we tested the hypothesis that HJG exerts neurotrophic factor-like effects to ameliorate memory impairment in Alzheimer disease (AD) model rats. First, we
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 70485-250MG | 04061833054550 |