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89270

Thymidine

Name: Thymidine
Brand: SIGMA

≥99.0% (HPLC), synthetic, powder

Synonym(s):

1-(2-Deoxy-β-D-ribofuranosyl)-5-methyluracil, 1-(2-Deoxy-β-D-ribofuranosyl)thymine, 2′-Deoxythymidine, Thymine deoxyriboside, dT

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₄N₂O₅

CAS Number:

50-89-5

Molecular Weight:

242.23

NACRES:

NA.51

PubChem Substance ID:

329769717

UNSPSC Code:

41106305

EC Number:

200-070-4

MDL number:

MFCD00006537

Beilstein/REAXYS Number:

89285

Assay:

≥99.0% (HPLC)

Biological source:

synthetic

Form:

powder

Solubility:

hot water: 1 g/10 mL

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Properties

Product Name

Thymidine, ≥99.0% (HPLC)

biological source

synthetic

Quality Level

200

assay

≥99.0% (HPLC)

form

powder

optical activity

[α]20/D +19±1°, c = 1% in H₂O

mp

185-190 °C, 186-188 °C (lit.)

solubility

hot water: 1 g/10 mL

SMILES string

CC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1

InChI key

IQFYYKKMVGJFEH-XLPZGREQSA-N

Description

Application

Thymidine has been used:

to culture human fibroblast cell lines.
in in vitro wound healing assay.
to culture various cancer cell lines.

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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The preferential selection of K65R in HIV-1 subtype C is attenuated by nucleotide polymorphisms at thymidine analogue mutation sites.

Cédric F Invernizzi et al.

The Journal of antimicrobial chemotherapy, 68(10), 2192-2196 (2013-06-12)

We recently reported the preferential selection of the K65R resistance mutation in subtype C HIV-1 compared with subtype B and showed the underlying mechanism to be dependent on subtype C-specific silent nucleotide polymorphisms, i.e. genomic mutations that change the genotype

Multiple immune factors are involved in controlling acute and chronic chikungunya virus infection.

Yee Suan Poo et al.

PLoS neglected tropical diseases, 8(12), e3354-e3354 (2014-12-05)

The recent epidemic of the arthritogenic alphavirus, chikungunya virus (CHIKV) has prompted a quest to understand the correlates of protection against virus and disease in order to inform development of new interventions. Herein we highlight the propensity of CHIKV infections

The impact of induction therapy on the homeostasis and function of regulatory T cells in kidney transplant patients.

Anne P Bouvy et al.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 29(8), 1587-1597 (2014-04-29)

To evaluate the influence of induction therapy on Tregs we investigated their origin, kinetics and function in kidney transplant patients after treatment with T-cell depleting rabbit antithymocyte globulin (rATG) or IL-2 receptor antagonist basiliximab. Flow cytometry was used to study

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Global Trade Item Number

SKU	GTIN
89270-1G	04061833075685
89270-25G	04061833416082
89270-5G	04061833075692