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A0384

Arcaine sulfate salt

Name: Arcaine sulfate salt
Brand: SIGMA

Synonym(s):

1,4-Diguanidinobutane sulfate salt

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About This Item

Empirical Formula (Hill Notation):

C₆H₁₆N₆ · H₂O₄S

CAS Number:

14923-17-2

Molecular Weight:

270.31

NACRES:

NA.77

PubChem Substance ID:

24277954

UNSPSC Code:

12352200

MDL number:

MFCD00050545

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

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Properties

biological source

synthetic (organic)

Quality Level

200

assay

≥98% (TLC)

form

powder

mp

>280 °C

solubility

1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

SMILES string

OS(O)(=O)=O.NC(=N)NCCCCNC(N)=N

InChI

1S/C6H16N6.H2O4S/c7-5(8)11-3-1-2-4-12-6(9)10;1-5(2,3)4/h1-4H2,(H4,7,8,11)(H4,9,10,12);(H2,1,2,3,4)

InChI key

RWTGFMPOODRXIM-UHFFFAOYSA-N

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)

Description

Application

Arcaine sulfate salt has been used as an N-methyl-d-aspartate (NMDA) receptor effector/antagonist:

to evaluate its effects on the acquisition of electrical kindling of the amygdala
to compare its effects with agmatine and MK801 on NMDA- or glutamate-induced neuronal damage
to study its effects on cell-free translation of synthetic polynucleotide

Biochem/physiol Actions

Arcaine sulfate salt (1,4-diguanidinobutane), a polyamine, is an antagonist of the polyamine binding site of the N-methyl-d-aspartate (NMDA) receptor. Arcaine, an agmatine analog, along with ifenprodil, might have a possibility for therapeutic management in epileptic disorders.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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The involvement of the polyamines binding sites at the NMDA receptor in creatine-induced spatial learning enhancement.

Mauro Schneider Oliveira et al.

Behavioural brain research, 187(1), 200-204 (2007-10-24)

Achievements made over the last years have highlighted the important role of creatine in health and disease. However, studies of its effect on cognition function have been limited. In the present study, we investigated the effect of creatine on early

Polyamines reduces lipid peroxidation induced by different pro-oxidant agents.

Nádia Aléssio Velloso Bellé et al.

Brain research, 1008(2), 245-251 (2004-05-18)

Polyamines, among other functions, are considered to act as a free radical scavenger and antioxidant. The quinolinic acid (QA), sodium nitroprusside (SNP) and iron (Fe+2) stimulate production of free radicals and lipid peroxidation. In the present study, we investigated the

Arcaine is a competitive antagonist of the polyamine site on the NMDA receptor.

I J Reynolds

European journal of pharmacology, 177(3), 215-216 (1990-02-27)

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Global Trade Item Number

SKU	GTIN
A0384-50MG	04061832088501