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A1260

Amantadine hydrochloride

Name: Amantadine hydrochloride
Brand: SIGMA

≥98% (TLC), powder, NMDA receptor antagonist

Synonym(s):

1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride, NSC 83653, Tricyclo[3.3.1.1^3,7]decan-1-amine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₇N · HCl

CAS Number:

665-66-7

Molecular Weight:

187.71

NACRES:

NA.77

PubChem Substance ID:

24277882

UNSPSC Code:

12352200

EC Number:

211-560-2

MDL number:

MFCD00074723

Beilstein/REAXYS Number:

4198854

Form:

powder

Quality level:

100

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Properties

Product Name

Amantadine hydrochloride,

form

powder

Quality Level

100

solubility

H₂O: 50 mg/mL, ethanol: soluble

originator

Endo

SMILES string

Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3

InChI

1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;

InChI key

WOLHOYHSEKDWQH-SOVZANNPSA-N

Description

General description

Amantadine hydrochloride {tricyclo-[3,3,1,1]- deean-l-amine hydrochloride is a drug, which has rimantadine hydrochloride as its analog.

Application

Amantadine hydrochloride has been used:

to determine its effectiveness in reducing surgery-induced cognitive impairment
to preincubate multipotent stem cells (MSCs), to investigate the cellular internalization pathway
to determine whether amantadine-attenuated sepsis-induces neuroinflammation and dysfunction of learning and memory
to preincubate primary cultured rat dental pulp stem cells (rDPSCs)
to determine the pathway of internalization

Biochem/physiol Actions

Amantadine hydrochloride is effective against influenza viruses both in vivo and in vitro. It is considered as an antagonist of the N-methyl-D-aspartate (NMDA) type glutamate receptor. Amantadine plays an important role in the release of dopamine, preventing dopamine reuptake and blocking microglial activation and neuroinflammation.

Dopamine releaser used to treat Parkinsonism and drug-induced extrapyramidal reactions.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Endo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.