A211000
DMT-2′O-TBDMS-rA(bz) Phosphoramidite
Synonym(s):
DMT-2’O-TBDMS-rA(bz) Amidite, N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-adenosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
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About This Item
biological source
non-animal source (no BSE/TSE risk)
product line
Proligo Reagents
assay
≥99% (31P-NMR), ≥99.0% (reversed phase HPLC)
form
powder
technique(s)
oligo synthesis: suitable
impurities
≤0.3 wt. % water content (Karl Fischer), ≤0.5% P(III) Impurities 100-169ppm (31P-NMR), ≤0.5% single Impurity (reversed phase HPLC), ≤3 wt. % residual Solvent content
color
white to off-white
λ
conforms (UV/VIS Identity)
suitability
conforms to structure for H-NMR, conforms to structure for LC-MS
nucleoside profile
base: adenosine
base protecting group: benzoyl
2' protecting group: TBDMS
5' protecting group: DMT
deprotection: standard
storage temp.
−20°C
SMILES string
COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4c(NC(=O)c5ccccc5)ncnc34)(c6ccccc6)c7ccc(OC)cc7
InChI
1S/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-46-44(33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)66-51(47(46)68-70(10,11)52(5,6)7)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/m1/s1
InChI key
FFXHNCNNHASXCT-RFMFGJHUSA-N
General description
Application
Features and Benefits
- Industry standard 2′O-TBDMS protective group
- Consistent lot-to-lot purity and performance
- Compatible with deprotection methods based on methylamine or AMA
- Standard RNA phosphoramidites provide excellent coupling results when used with ETT or BTT as activator; best results are obtained with Activator 42
- Capping with standard acetic anhydride capping reagent rather than with Fast Deprotection Cap A
- Manufactured under a certified ISO 9001 quality system
Other Notes
- Catalytic agents (ribozymes)
- Affinity ligands (aptamers)
- Agents to induce gene silencing (RNA interference)
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| A211000-500G | 04061832024370 |
| A211000-C | 04061826587164 |
| A211000-100G | 04061833311424 |
| A211000-AGL | 04061826587133 |
| A211000-AVC | 04061826587140 |
| A211000-BIO | 04061826587157 |