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A2202

ω-Agatoxin TK

Name: ω-Agatoxin TK
Brand: SIGMA

~98% (HPLC), powder

Synonym(s):

ω-Aga-TK

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About This Item

Empirical Formula (Hill Notation):

C₂₁₅H₃₃₇N₆₅O₇₀S₁₀

CAS Number:

158484-42-5

Molecular Weight:

5273.02

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD00286234

Form:

powder

Assay:

~98% (HPLC)

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Properties

assay

~98% (HPLC)

Quality Level

200

form

powder

solubility

H₂O: soluble (Aqueous stock solution is stable for 1 month at 2-8 °C and for several months at -20 °C.)

storage temp.

−20°C

Gene Information

human ... CACNA1A(773)
mouse ... CACNA1A(12286)
rat ... CACNA1A(25398)

Description

Biochem/physiol Actions

Toxin found in the venom of the funnel web spider, Agelenopsis aptera. Potent, selective P-type and Q-type calcium-channel blocker, without effect on L-type, N-type, or T-type calcium channels. Used to differentiate the types of calcium channel active during various physiological processes

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Calcium in sympathetic boutons of rat superior cervical ganglion during facilitation, augmentation and potentiation.

Y Q Lin et al.

Journal of the autonomic nervous system, 73(1), 26-37 (1998-11-10)

The sympathetic preganglionic nerve terminals of the rat superior cervical ganglion were loaded with the calcium indicator oregon green 488 BAPTA-1 to measure the change in calcium concentration in the terminal boutons, (delta[Ca2+]b) following short (1 or 5 impulses) and

A novel peptide from funnel web spider venom, omega-Aga-TK, selectively blocks, P-type calcium channels.

T Teramoto et al.

Biochemical and biophysical research communications, 196(1), 134-140 (1993-10-15)

In the course of purification of omega-Aga-IVA, a specific P-type calcium channel blocker, from the venom of Agelenopsis aperta we discovered a novel peptide. This peptide, named omega-agatoxin Tsukuba (omega-Aga-TK), also blocked P-type channels and was twelve times more abundant

A novel type of calcium channel sensitive to omega-agatoxin-TK in cultured rat cerebral cortical neurons.