A2504
6-Aminocaproic acid
≥99% (titration), powder
Synonym(s):
ε-Aminocaproic acid, 6-Aminohexanoic acid, EACA
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About This Item
Linear Formula:
H2N(CH2)5CO2H
CAS Number:
Molecular Weight:
131.17
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-469-3
Beilstein/REAXYS Number:
906872
MDL number:
Assay:
≥99% (titration)
Form:
powder
biological source
synthetic
Quality Level
assay
≥99% (titration)
form
powder
technique(s)
cell culture | mammalian: suitable
color
white
mp
207-209 °C (dec.) (lit.)
solubility
H2O: 50 mg/mL
SMILES string
NCCCCCC(O)=O
InChI
1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
InChI key
SLXKOJJOQWFEFD-UHFFFAOYSA-N
Gene Information
human ... PLAT(5327), PLG(5340)
rat ... Ppm1a(24666)
Application
EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.
Biochem/physiol Actions
EACA is reported to inhibit chymotrypsin, Factor VIIa, lysine carboxypeptidase, plasmin, and plasminogen activator.
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis.
Lysine analog. Promotes rapid dissociation of plasmin, thereby inhibiting the activation of plasminogen and subsequent fibrinolysis. Reported to inhibit plasminogen binding to activated platelets. An early report indicated that it inhibits the activation of the first component of the complement system. Binds and inactivates Carboxypeptidase B.
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Storage Class
11 - Combustible Solids
flash_point_f
404.6 - 408.2 °F
flash_point_c
207 - 209 °C
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Articles
Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| A2504-500G | 04061833350355 |
| A2504-100G | 04061833350331 |
| A2504-1KG | 04061826740866 |
| A2504-25G | 04061833350348 |
| A2504-5KG | 04061832938813 |