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A2754

Adenosine 5′-diphosphate sodium salt

Name: Adenosine 5&#8242;-diphosphate sodium salt
Brand: SIGMA

≥95% (HPLC), bacterial, powder

Synonym(s):

ADP sodium salt, ADP

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₅N₅O₁₀P₂

CAS Number:

20398-34-9

Molecular Weight:

427.20

UNSPSC Code:

41106305

eCl@ss:

32160414

PubChem Substance ID:

24890690

NACRES:

NA.51

Assay:

≥95% (HPLC)

Biological source:

bacterial

Form:

powder

Solubility:

water: 50 mg/mL, clear to hazy, colorless

Storage temp.:

−20°C

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Properties

Product Name

Adenosine 5′-diphosphate sodium salt, bacterial, ≥95% (HPLC)

biological source

bacterial

Quality Level

300

assay

≥95% (HPLC)

form

powder

solubility

water: 50 mg/mL, clear to hazy, colorless

storage temp.

−20°C

SMILES string

[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(O)=O)C(O)C3O

InChI

1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

InChI key

XTWYTFMLZFPYCI-KQYNXXCUSA-N

Gene Information

human ... HSP90AA1(3320), P2RY1(5028)

Description

General description

Adenosine 5′-diphosphate (ADP) is an adenine nucleotide involved in energy storage and nucleic acid metabolism via its conversion into ATP by FOF1-ATP synthases. ADP can also be obtained by adenylate monophosphate (AMP) reaction catalyzed by adenylate kinase. ADP is a platelet agonist that is secreted from platelet dense granules. It promotes platelet activation through its interaction with ADP receptors P2Y1 and P2Y12. Upon conversion of ADP to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors.

Application

Adenosine 5′-diphosphate sodium salt has been used:

as a positive control of platelet aggregation to analyze antiplatelet activity of purified disintegrin by aggregometery.
in the preparation of stock solution for a mito stress test.
as a positive control in flow cytometry analysis to study the effect of pentameric C-reactive protein (pCRP) and monomeric CRP (mCRP) on the CD62p (P-selectin) expression of platelets.
as a platelet agonist to stimulate platelet aggregation.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Protocols

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

LC/MS Analysis of Nucleotides SeQuant^® ZIC^®-cHILIC – Effect of pH

ZIC^®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

Mechanism of ATP turnover inhibition in the EJC.

Klaus H Nielsen et al.

RNA (New York, N.Y.), 15(1), 67-75 (2008-11-27)

The exon junction complex (EJC) is deposited onto spliced mRNAs and is involved in many aspects of mRNA function. We have recently reconstituted and solved the crystal structure of the EJC core made of MAGOH, Y14, the most conserved portion

Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo.

Richard C Jin et al.

Circulation, 123(18), 1963-1973 (2011-04-27)

Glutathione peroxidase-3 (GPx-3) is a selenocysteine-containing plasma protein that scavenges reactive oxygen species in the extracellular compartment. A deficiency of this enzyme has been associated with platelet-dependent thrombosis, and a promoter haplotype with reduced function has been associated with stroke

Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.

Tsui-Fen Chou et al.

Journal of molecular biology, 426(15), 2886-2899 (2014-06-01)

The p97 AAA (ATPase associated with diverse cellular activities), also called VCP (valosin-containing protein), is an important therapeutic target for cancer and neurodegenerative diseases. p97 forms a hexamer composed of two AAA domains (D1 and D2) that form two stacked

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Global Trade Item Number

SKU	GTIN
A2754-100MG	04061835540556
A2754-1G	04061835488773
A2754-500MG	04061835517602
A2754-5X1G	04061835553167