A6816
(±)-AMPA
solid
Synonym(s):
(±)-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid hydrate
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About This Item
Empirical Formula (Hill Notation):
C7H10N2O4
Molecular Weight:
186.17
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Form:
solid
Quality level:
form
solid
Quality Level
color
white
solubility
H2O: 1 mg/mL (warm), 0.1 M HCl: 3.5 mg/mL, 0.1 M NaOH: 4.3 mg/mL, DMSO: 4.3 mg/mL, 1 M HCl: 50 mg/mL
SMILES string
O.Cc1onc(O)c1CC(N)C(O)=O
InChI
1S/C7H10N2O4.H2O/c1-3-4(6(10)9-13-3)2-5(8)7(11)12;/h5H,2,8H2,1H3,(H,9,10)(H,11,12);1H2
InChI key
HFISYNCCKQHIAM-UHFFFAOYSA-N
Gene Information
Application
(±)-AMPA has been used:
- in vivo
- whole-cell patch-clamp recording in Müller glial cells
- to test its excitotoxic effects in hippocampal slice cultures
- in retinal horizontal cells (HCs) culture to test its effect on Ca2+ signals
Biochem/physiol Actions
Potent excitatory amino acid that interacts selectively with central AMPA/kainate receptors.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Sheyla Mejia-Gervacio
The Journal of physiology, 590(19), 4663-4671 (2012-08-15)
A cholinergic synaptic input has been highlighted in recent years as an important modulator of motoneuron excitability. In the present study, it was examined whether, as in other regions, the cholinergic inputs on spinal motoneurons modulate the glutamatergic synaptic activity
Carlos Gonzalez-Islas et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(39), 13597-13607 (2012-09-28)
Endocannabinoid signaling has been shown to mediate synaptic plasticity by retrogradely inhibiting presynaptic transmitter release in several systems. We found that endocannabinoids act tonically to regulate AMPA miniature postsynaptic current (mPSC) frequency in embryonic motor circuits of the chick spinal
Joonwoo Lee et al.
Biological & pharmaceutical bulletin, 36(3), 331-338 (2013-03-02)
Various effects of acorn extract have been reported including antioxidant activity, cytotoxicity against cancer cells, and the levels of acetylcholine and its related enzyme activities in the dementia mouse models. However, it is unclear whether acorn extract inhibits glutamate-induced calcium
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A6816-5MG | 04061833001981 |
| A6816-10MG | 04061833001974 |
| A6816-1MG | 04061833382882 |