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A9186

Alcian Blue 8GX

BioReagent, suitable for detection of glycoproteins

Synonym(s):

Alcian Blue, Ingrain Blue 1

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About This Item

Empirical Formula (Hill Notation):
C56H68Cl4CuN16S4
CAS Number:
33864-99-2
Molecular Weight:
1298.86
UNSPSC Code:
12171500
NACRES:
NA.32
PubChem Substance ID:
24891421
EC Number:
251-705-7
Colour Index Number:
74240
MDL number:
MFCD00010720
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product line

BioReagent

form

powder

composition

Dye content, ~50%

technique(s)

electrophoresis: suitable

suitability

suitable for detection of glycoproteins

SMILES string

[Cl-].[Cl-].[Cl-].[Cl-].CN(C)C(\SCc1ccc2c3nc(nc4n5[Cu]n6c(nc7nc(nc5c8cc(CS\C(N(C)C)=[N+](\C)C)ccc48)c9ccc(CS\C(N(C)C)=[N+](\C)C)cc79)c%10ccc(CS\C(N(C)C)=[N+](\C)C)cc%10c6n3)c2c1)=[N+](/C)C

InChI

1S/C56H68N16S4.4ClH.Cu/c1-65(2)53(66(3)4)73-29-33-17-21-37-41(25-33)49-57-45(37)62-50-43-27-35(31-75-55(69(9)10)70(11)12)19-23-39(43)47(59-50)64-52-44-28-36(32-76-56(71(13)14)72(15)16)20-24-40(44)48(60-52)63-51-42-26-34(18-22-38(42)46(58-51)61-49)30-74-54(67(5)6)68(7)8;;;;;/h17-28H,29-32H2,1-16H3;4*1H;/q+2;;;;;+2/p-4

InChI key

CKLBXIYTBHXJEH-UHFFFAOYSA-J

General description

Alcian Blue 8GX is a cationic phthalocyanine dye. It has an ability to interact with sulphated glycosaminoglycan. It is used as a counterstain to visualize histological tissue sections. In addition, alcian blue 8GX also aids in the in-situ quantification of marine biofilms produced by marine bacteria.

Application

Alcian Blue 8GX has been used:
  • for the quantification of sulphated glycosaminoglycan
  • to stain differentiated chondrocytes to access proteoglycan′s synthesis by these cells
  • to stain Multi-lineage differentiation of hemangioma-derived perivascular cells (Hem-PCs)
  • in histological staining to detect neutral and charged carbohydrate residues

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCJ3543
MKCH2605
MKCD8755
048K1381
096K0755

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Chloe Moreau et al.
Current biology : CB, 29(1), 35-50 (2018-12-18)
Limb position along the body is highly consistent within one species but very variable among vertebrates. Despite major advances in our understanding of limb patterning in three dimensions, how limbs reproducibly form along the antero-posterior axis remains largely unknown. Hox
Elke A F Van Doren et al.
Journal of nanobiotechnology, 9, 17-17 (2011-05-17)
Transmission electron microscopy (TEM) remains an important technique to investigate the size, shape and surface characteristics of particles at the nanometer scale. Resulting micrographs are two dimensional projections of objects and their interpretation can be difficult. Recently, electron tomography (ET)
Amr M Ghaleb et al.
Molecular cancer research : MCR, 6(12), 1920-1927 (2008-12-17)
The zinc finger-containing transcription factor, Krüppel-like factor 4 (KLF4), inhibits cell proliferation. An in vivo tumor-suppressive role for KLF4 is shown by the recent finding that Klf4 haploinsufficiency in Apc(Min/+) mice promotes intestinal tumorigenesis. Studies also show that KLF4 is
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Global Trade Item Number

SKUGTIN
A9186-25G04061833401460
A9186-10G04061833401453