B1758
Biocytin hydrochloride
≥98% (TLC), suitable for drug transporter assays
Synonym(s):
Nε-Biotinyl-L-lysine
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About This Item
Empirical Formula (Hill Notation):
C16H28N4O4S · xHCl
CAS Number:
Molecular Weight:
372.48 (free base basis)
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:
Product Name
Biocytin hydrochloride, ≥98% (TLC)
Quality Level
assay
≥98% (TLC)
form
powder
technique(s)
drug transporter assay: suitable
color
white to off-white
storage temp.
−20°C
SMILES string
Cl.NC(CCCCNC(=O)CCCCC1SCC2NC(=O)NC12)C(O)=O
InChI
1S/C16H28N4O4S.ClH/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14;/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24);1H
InChI key
FMGQMNFQNPUYBS-UHFFFAOYSA-N
Application
- Biotinylated dextran amine and biocytin hydrochloride are useful tracers for the study of retinal projections in the frog.: This paper highlights the application of biocytin hydrochloride in tracing retinal projections in amphibians. The study demonstrates the efficacy of biocytin hydrochloride in neuroanatomical mapping, facilitating research in visual system development and function (Scalia et al., 1997).
Biochem/physiol Actions
Biocytin is used as a substrate to study the specificity and kinetics of biotinidase(s), to measure biotinidase deficiency and as a model compound to study various uptake mechanisms of cells and tissues.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Isabel D Lamb-Echegaray et al.
Brain structure & function, 224(9), 3353-3371 (2019-11-16)
The multimodal lateral cortex of the inferior colliculus (LCIC) exhibits a modular-extramodular micro-organization that is evident early in development. In addition to a set of neurochemical markers that reliably highlight its modular-extramodular organization (e.g. modules: GAD67-positive, extramodular zones: calretinin-positive, CR)
Barbara Baur et al.
Brain research, 925(2), 111-121 (2002-01-17)
Uptake of biocytin and biotin was investigated in cultured transformed variants of neuronal (NB2a neuroblastoma) and glial (C6 astrocytoma) CNS cells. NB2a cells took up both compounds but biocytin was transported more efficiently than biotin in the nanomolar concentration range.
Aysun Pabuçcuoğlu et al.
Journal of pediatric gastroenterology and nutrition, 34(1), 59-62 (2001-12-26)
Biotinidase is the enzyme responsible for liberating the vitamin biotin from biocytin and dietary protein-bound vitamin. Individuals lacking biotinidase activity become biotin deficient. Because the liver is the major source of plasma biotinidase, chronic liver diseases can lead to decreased
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B1758-100MG | 04061833426340 |
| B1758-25MG | 04061832415161 |
| B1758-250MG | 04061833426357 |
| B1758-50MG | 04061832415178 |