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B2417

Benzamil hydrochloride hydrate

≥98% (HPLC), ENaC and NCX inhibitor, solid

Synonym(s):

N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate

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About This Item

Empirical Formula (Hill Notation):
C13H14ClN7O · HCl · xH2O
CAS Number:
161804-20-2
Molecular Weight:
356.21 (anhydrous basis)
MDL number:
MFCD28147597
UNSPSC Code:
12352200
PubChem Substance ID:
24278262
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
desiccated
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Product Name

Benzamil hydrochloride hydrate, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

yellow

solubility

methanol: 10 mg/mL, DMSO: >20 mg/mL

storage temp.

2-8°C

SMILES string

O.Cl.Nc1nc(N)c(nc1Cl)C(=O)NC(=N)NCc2ccccc2

InChI

1S/C13H14ClN7O.ClH.H2O/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7;;/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22);1H;1H2

InChI key

YAJQRPFIYXRNKS-UHFFFAOYSA-N

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)

Biochem/physiol Actions

Selective and potent blocker of Na+/H+ and Na+/Ca2+ channels

Features and Benefits

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Nω-Benzyl derivative of amiloride.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
066M4614V
015M4605V
073M4620V
059K46102V
059K4610V

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J W Lane et al.
British journal of pharmacology, 106(2), 283-286 (1992-06-11)
1. Patch clamp recording techniques have been used to compare the block caused by amiloride and some of its structural analogues of the mechanosensitive (MS) cation selective channel in frog (Xenopus laevis) oocytes. 2. Like amiloride, the amiloride analogues dimethylamiloride
A Catalina Vélez-Ortega et al.
eLife, 6 (2017-03-30)
Mechanotransducer channels at the tips of sensory stereocilia of inner ear hair cells are gated by the tension of 'tip links' interconnecting stereocilia. To ensure maximal sensitivity, tip links are tensioned at rest, resulting in a continuous influx of Ca2+
G N Pierce et al.
The Journal of pharmacology and experimental therapeutics, 265(3), 1280-1291 (1993-06-01)
Amiloride and its derivatives (benzamil, dichlorobenzamil, 5-(N,N-dimethyl)-amiloride, 5-(N-ethyl-N-isopropyl)-amiloride, (N,N-hexamethylene)- amiloride and 5-(N-methyl-N-isobutyl)-amiloride) are commonly used as selective blockers of Na+/Ca++ exchange or Na+/H+ exchange. Very little information is currently available regarding their effects on cardiac performance. It was observed that
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Global Trade Item Number

SKUGTIN
B2417-50MG04061832569246
B2417-10MG04061833426777