B4153
Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride
~95%
Synonym(s):
Boc-Gln-Ala-Arg-AMC hydrochloride, Boc-Gln-Ala-Arg-Mca hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C29H42N8O8 · HCl
CAS Number:
Molecular Weight:
667.15
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
assay
~95%
Quality Level
form
powder
solubility
methanol: 50 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
CC(NC(=O)C(CCC(N)=O)NC(=O)OC(C)(C)C)C(=O)NC(CCCNC(N)=N)C(=O)Nc1ccc2C(C)=CC(=O)Oc2c1
InChI
1S/C29H42N8O8/c1-15-13-23(39)44-21-14-17(8-9-18(15)21)35-26(42)19(7-6-12-33-27(31)32)36-24(40)16(2)34-25(41)20(10-11-22(30)38)37-28(43)45-29(3,4)5/h8-9,13-14,16,19-20H,6-7,10-12H2,1-5H3,(H2,30,38)(H,34,41)(H,35,42)(H,36,40)(H,37,43)(H4,31,32,33)
InChI key
LQSLBVXESNRILG-UHFFFAOYSA-N
General description
Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride is a fluorogenic and cell-permeable trypsin substrate.
Substrate for trypsin
Application
Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin hydrochloride has been used as a fluorogenic substrate to measure the enzymatic activity of trypsin.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
常规特殊物品
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Sudarshan R Malla et al.
Cellular and molecular life sciences : CMLS, 77(9), 1811-1825 (2019-08-01)
Premature intrapancreatic trypsinogen activation is widely regarded as an initiating event for acute pancreatitis. Previous studies have alternatively implicated secretory vesicles, endosomes, lysosomes, or autophagosomes/autophagolysosomes as the primary site of trypsinogen activation, from which a cell-damaging proteolytic cascade originates. To
José Manuel Mazón-Suástegui et al.
Homeopathy : the journal of the Faculty of Homeopathy, 109(1), 3-13 (2019-08-28)
This research aimed to observe the effect of homeopathically prepared Vibrio parahaemolyticus (ViP) and V. alginolyticus (ViA) and the commercial homeopathic compound Similia (Phosphoricum acidum and Silicea terra) on the digestive enzyme activities of Seriola rivoliana juveniles under usual culture
S Kawabata et al.
European journal of biochemistry, 172(1), 17-25 (1988-02-15)
Seventy-four peptide amides of 7-amino-4-methylcoumarin (Mec) of the type Boc-Xaa-Yaa-Arg-NH-Mec were newly synthesized and tested to find specific substrates for blood-clotting proteases and trypsin. The Xaa and Yaa residues of these substrates have been replaced by 12 and 15 different
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B4153-5MG | 04061832921303 |