B4560
6-Bnz-cAMP sodium salt
≥98% (HPLC)
Synonym(s):
N6-Benzoyladenosine-3′,5′-cyclic monophosphate sodium salt
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About This Item
Empirical Formula (Hill Notation):
C17H15N5O7PNa
CAS Number:
Molecular Weight:
455.29
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
packaging
vial of 10 μmol
storage condition
desiccated
color
white
solubility
H2O: freely soluble
shipped in
dry ice
storage temp.
−70°C
SMILES string
[Na+].O[C@@H]1[C@@H]2OP([O-])(=O)OC[C@H]2O[C@H]1n3cnc4c(NC(=O)c5ccccc5)ncnc34
InChI
1S/C17H16N5O7P.Na/c23-12-13-10(6-27-30(25,26)29-13)28-17(12)22-8-20-11-14(18-7-19-15(11)22)21-16(24)9-4-2-1-3-5-9;/h1-5,7-8,10,12-13,17,23H,6H2,(H,25,26)(H,18,19,21,24);/q;+1/p-1/t10-,12-,13-,17-;/m1./s1
InChI key
SPYGSKQRPXISIB-FKVBDRBCSA-M
Biochem/physiol Actions
6-Bnz-cAMP is a membrane-permeable and selective cAMP-dependent protein kinase (PKA) activator.
6-Bnz-cAMP is a membrane permeable and selective cAMP-dependent protein kinase (PKA) activator. For preferential stimulation of cAK type I, a combination with the site B selective analog 8-HA-cAMP or 8-AHA-cAMP can be used.
Features and Benefits
This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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R Bøe et al.
British journal of cancer, 72(5), 1151-1159 (1995-11-01)
8-Cl-cAMP and 8-NH2-cAMP induced MCF-7 cell death. The type(s) of cell death were studied in more detail and compared with the cell death type (apoptosis) induced by okadaic acid, an inhibitor of serine/threonine phosphatases. By morphological criteria dying cells showed
K E Fladmark et al.
Hepatology (Baltimore, Md.), 25(4), 847-855 (1997-04-01)
The hepatocytes in the mature normal liver are tightly coupled through gap junctions, except during compensatory hyperplasia (regeneration) after partial hepatectomy when the gap junctions become down-regulated. The significance of this down-regulation has been a long-standing enigma. The present study
N A Abumrad et al.
The Journal of biological chemistry, 261(28), 13082-13086 (1986-10-05)
Membrane transport of long chain fatty acids in the isolated adipocyte can be stimulated 5-10-fold by epinephrine (Abumrad, N. A., Perry, P. R., and Whitesell, R. R. (1985) J. Biol. Chem. 260, 9969-9971). This study shows that isoproterenol and norepinephrine
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B4560-1VL | 04061833429815 |