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B6311

BTO-1

Name: BTO-1
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide

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About This Item

Empirical Formula (Hill Notation):

C₉H₄N₄O₄S

CAS Number:

40647-02-7

Molecular Weight:

264.22

NACRES:

NA.77

PubChem Substance ID:

329773275

UNSPSC Code:

12352200

MDL number:

MFCD11045282

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

tan

solubility

H₂O: <2 mL/mL, DMSO: ≥5 mg/mL

storage temp.

2-8°C

SMILES string

NC(=O)c1sc2c(cc(cc2[n+]1[O-])C#N)[N+]([O-])=O

InChI

1S/C9H4N4O4S/c10-3-4-1-5-7(6(2-4)13(16)17)18-9(8(11)14)12(5)15/h1-2H,(H2,11,14)

InChI key

FKRBAXZAJBBIAJ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

BTO-1 is a polo-like kinase (Plk) inhibitor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.

Mark E Burkard et al.

PLoS biology, 7(5), e1000111-e1000111 (2009-05-27)

Animal cells initiate cytokinesis in parallel with anaphase onset, when an actomyosin ring assembles and constricts through localized activation of the small GTPase RhoA, giving rise to a cleavage furrow. Furrow formation relies on positional cues provided by anaphase spindle

The transforming parasite Theileria co-opts host cell mitotic and central spindles to persist in continuously dividing cells.

Conrad von Schubert et al.

PLoS biology, 8(9) (2010-10-12)

The protozoan parasite Theileria inhabits the host cell cytoplasm and possesses the unique capacity to transform the cells it infects, inducing continuous proliferation and protection against apoptosis. The transforming schizont is a multinucleated syncytium that resides free in the host

Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.

Keiko Yata et al.

Molecular cell, 45(3), 371-383 (2012-02-14)

Homologous recombination (HR) plays an important role in the maintenance of genome integrity. HR repairs broken DNA during S and G2 phases of the cell cycle but its regulatory mechanisms remain elusive. Here, we report that Polo-like kinase 1 (Plk1)

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Global Trade Item Number

SKU	GTIN
B6311-25MG	04061832444581
B6311-5MG	04061832444598