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C160

CGP-42112A

synthetic, ≥95%, Angiotensin II receptor antagonist, solid

Synonym(s):

Nα-Nicotinoyl-Tyr-(Nα-Cbz-Arg)-Lys-His-Pro-Ile

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About This Item

Empirical Formula (Hill Notation):
C52H69N13O11
CAS Number:
127060-75-7
Molecular Weight:
1052.18
NACRES:
NA.77
PubChem Substance ID:
24892424
UNSPSC Code:
12352200
MDL number:
MFCD00133611
Beilstein/REAXYS Number:
8184948
Assay:
≥95%
Form:
solid
Quality level:
200
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Product Name

CGP-42112A, ≥95%, synthetic, solid

biological source

synthetic

Quality Level

200

assay

≥95%

form

solid

color

white

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc3ccccc3)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)c5cccnc5)C(O)=O

InChI

1S/C52H69N13O11/c1-3-32(2)43(50(73)74)64-48(71)42-17-11-25-65(42)49(72)41(27-36-29-56-31-59-36)62-46(69)39(60-47(70)40(26-33-18-20-37(66)21-19-33)61-44(67)35-14-9-22-55-28-35)15-7-8-23-57-45(68)38(16-10-24-58-51(53)54)63-52(75)76-30-34-12-5-4-6-13-34/h4-6,9,12-14,18-22,28-29,31-32,38-43,66H,3,7-8,10-11,15-17,23-27,30H2,1-2H3,(H,56,59)(H,57,68)(H,60,70)(H,61,67)(H,62,69)(H,63,75)(H,64,71)(H,73,74)(H4,53,54,58)/t32-,38-,39-,40-,41-,42-,43-/m0/s1

InChI key

UXGNARZDONUMMK-LRMQDCNJSA-N

Gene Information

human ... AGTR2(186)
rat ... AGTR2(11609)

Application

CGP-42112A has been used:
  • in the isolation of RNA from fibroblast-like synoviocytes from rheumatoid arthritis patients (RA-FLS)
  • to study its effects on the ERK2 phosphorylation in the cardiomyoblast cell line
  • as a stimulator of angiotensin II type 2 (AT2) receptor to study its effects on human regional hemodynamic responses mediated by AT2 receptors

Biochem/physiol Actions

CGP-42112A is a potent angiotensin II type 2 receptor (AT2R) agonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
SLCL1541
SLCK9693
SLCK4293
SLCD4997
SLBZ5320

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Nancy J Hong et al.
Hypertension (Dallas, Tex. : 1979), 60(3), 765-769 (2012-07-11)
NO reduces NaCl absorption by thick ascending limbs (TALs) by inhibiting the Na/K/2Cl cotransporter (NKCC2). We have shown that NO-induced inhibition of Na transport is reduced in Dahl salt-sensitive rat (SS) TALs. Angiotensin II increases NO production in TALs via
E Chamoux et al.
The Journal of clinical endocrinology and metabolism, 84(12), 4722-4730 (1999-12-22)
The aim of this study was to establish a link between the highly expressed angiotensin II (Ang II) type 2 receptor (AT2) in human fetal adrenal cells and the proposed apoptotic activity in the center of the gland. There was
L Laflamme et al.
The Journal of biological chemistry, 271(37), 22729-22735 (1996-09-13)
In the present study, 3-day treatment of nondifferentiated NG108-15 cells with 100 nM angiotensin II (Ang II) induces morphological differentiation of neuronal cells characterized by the outgrowth of neurites. These morphological changes are correlated with an increase in the level
View All Related Papers

Global Trade Item Number

SKUGTIN
C160-1MG04061826152515
C160-5MG04061833467770