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Merck
CN

C5134

2-Chloroadenosine

adenosine A1 receptor agonist, powder

Synonym(s):

2-CADO, 6-Amino-2-chloropurine riboside

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About This Item

Empirical Formula (Hill Notation):
C10H12ClN5O4
CAS Number:
Molecular Weight:
301.69
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-678-3
MDL number:
Beilstein/REAXYS Number:
43957
Form:
powder
Quality level:
Technical Service
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Product Name

2-Chloroadenosine,

form

powder

Quality Level

SMILES string

Nc1nc(Cl)nc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O

InChI

1S/C10H12ClN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1

InChI key

BIXYYZIIJIXVFW-UUOKFMHZSA-N

Gene Information

Application

2-Chloroadenosine has been used:
  • as an agonist of adenosine receptors (A1R) in dorsal hippocampus (DH) and ventral hippocampus (VH) of mice
  • as a component of artificial cerebrospinal fluid (aCSF) for electrophysiological experiments using hippocampal slices
  • as an internal standard in solid phase extraction coupled with liquid chromatography-tandem mass spectrometry (XLC-MS/MS) for the quantification of certain metabolites from axonal lysates and dorsal root ganglia (DRG) neurons

Biochem/physiol Actions

2-Chloroadenosine is an analog of adenosine. It is an adenosine A1 receptor agonist. It might possess anti-oxidant property.


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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2-Chloroadenosine decreases long-term potentiation in the hippocampal CA1 area of the rat
de Mendoncca A and Ribeiro J A
Neuroscience Letters, 118(1), 107-111 (1990)
The effect of 2-chloroadenosine on lipid peroxide level during experimental cerebral ischemia-reperfusion in gerbils
Yavuz O, et al.
Free Radical Biology & Medicine, 22(1-2), 337-341 (1997)
Robert O Hughes et al.
Cell reports, 34(1), 108588-108588 (2021-01-07)
Axonal degeneration is responsible for disease progression and accumulation of disability in many neurodegenerative conditions. The axonal degenerative process can generate a metastable pool of damaged axons that remain structurally and functionally viable but fated to degenerate in the absence



Global Trade Item Number

SKUGTIN
C5134-10MG04061832089874
C5134-50MG04061832089898
C5134-1G04061825982076
C5134-250MG04061832089881