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C7527

Choline chloride

Name: Choline chloride
Brand: SIGMA

BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98%

Synonym(s):

(2-Hydroxyethyl)trimethylammonium chloride

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About This Item

Linear Formula:

(CH₃)₃N(Cl)CH₂CH₂OH

CAS Number:

67-48-1

Molecular Weight:

139.62

UNSPSC Code:

12352205

NACRES:

NA.75

PubChem Substance ID:

24892968

EC Number:

200-655-4

Beilstein/REAXYS Number:

3563126

MDL number:

MFCD00011721

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Properties

biological source

synthetic (organic)

Quality Level

300

product line

BioReagent

assay

≥98%

form

crystals

mol wt

M_w 139.62 g/mol

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable, cell culture | plant: suitable

color

white

pH

5.0-6.5 (25 °C, 140 g/L)

mp

302-305 °C (dec.) (lit.)

solubility

H₂O: 50 mg/mL

SMILES string

[Cl-].C[N+](C)(C)CCO

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

InChI key

SGMZJAMFUVOLNK-UHFFFAOYSA-M

Description

General description

Choline chloride is a quaternary ammonium salt and associates with hydrogen bond donors (HBD). It is essential for the vital physiological functions and is used as a nutritional additive. Choline is a source of methyl groups for methyl-transfer reactions.

Choline acetyltransferase substrate

Application

Choline chloride has been used:

as a component of choline acetyltransferase (ChAT) buffer and for choline uptake in cultured human neuroblastoma (SK-N-SH) cells
for choline standard curve generation for quantifying phospholipase D (PLD) activity
as a component of slice solution for the dissection of entorhinal-hippocampal brain slices

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Reporter lines based on the gexp02 promoter enable early quantification of sexual conversion rates in the malaria parasite Plasmodium falciparum.

Harvie P Portugaliza et al.

Scientific reports, 9(1), 14595-14595 (2019-10-12)

Transmission of malaria parasites from humans to mosquito vectors requires that some asexual parasites differentiate into sexual forms termed gametocytes. The balance between proliferation in the same host and conversion into transmission forms can be altered by the conditions of

Functional calcium imaging in developing cortical networks

Dawitz J, et al.

Journal of Visualized Experiments, 119(56), e3550-e3550 (2011)

Determination of high-affinity choline uptake (HACU) and choline acetyltransferase (ChAT) activity in the same population of cultured cells

Ray B, et al.

Brain Research, 1297(11), 160-168 (2009)

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Global Trade Item Number

SKU	GTIN
C7527-100G	04061833512791
C7527-1KG	04061833512807
C7527-500G	04061833512920