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C9538

Coenzyme Q₁₀

Name: Coenzyme&#160;Q<SUB>10</SUB>
Brand: SIGMA

≥98% (HPLC), powder, antioxidant

Synonym(s):

Q-10, CoQ10, Ubiquinone 50, Ubiquinone-10

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About This Item

Empirical Formula (Hill Notation):

C₅₉H₉₀O₄

CAS Number:

303-98-0

Molecular Weight:

863.34

NACRES:

NA.77

PubChem Substance ID:

24893170

UNSPSC Code:

12352200

EC Number:

206-147-9

MDL number:

MFCD00042919

Beilstein/REAXYS Number:

1900141

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

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Properties

Product Name

Coenzyme Q₁₀, ≥98% (HPLC)

Quality Level

200

assay

≥98% (HPLC)

form

powder

color

yellow to dark orange

mp

49 °C

application(s)

cell analysis

storage temp.

−20°C

SMILES string

O=C(C(OC)=C1OC)C(C/C=C(C)/CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)\C)\C)\C)\C)\C)=C(C)C1=O

InChI

1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

InChI key

ACTIUHUUMQJHFO-UPTCCGCDSA-N

Description

General description

Coenzyme Q (CoQ), also known as ubiquinone, is a lipid-soluble antioxidant and is an essential component of the mitochondrial electron transport chain. The molecule contains a biologically active quinone with a benzoquinone ring and an isoprenoid sidechain. Q10 is synthesized in the cytoplasm and mitochondria () which generates ATP through aerobic cellular respiration. CoQ10 is required for the optimal functioning of the immune system and for cardiovascular health (). The ability to repress inflammatory gene expression exhibits its anti-inflammatory property ( ) Genetic failure or ageing results in CoQ10 deficiency, indicated by suppression of immune function. ()

Application

Coenzyme Q10 (CoQ10) has been used:

as a bioactive compound to study its immune modulating properties in vitro
as a standard for high-performance liquid chromatography
to study its effect on exercised rat aorta
in the cellular CoQ uptake assay

Biochem/physiol Actions

Coenzyme Q10 is an endogenous cellular antioxidant and an essential component of the electron transfer chain. CoQ10 takes part in aerobic cellular respiration and generation of energy in the form of ATP.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

膳食抗氧化剂

抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

Discover Bioactive Small Molecules for Lipid Signaling Research

Dependence of brown adipose tissue function on CD36-mediated coenzyme Q uptake.

Courtney M Anderson et al.

Cell reports, 10(4), 505-515 (2015-01-27)

Brown adipose tissue (BAT) possesses the inherent ability to dissipate metabolic energy as heat through uncoupled mitochondrial respiration. An essential component of the mitochondrial electron transport chain is coenzyme Q (CoQ). While cells synthesize CoQ mostly endogenously, exogenous supplementation with

Effects of inhibitors of hydroxymethylglutaryl coenzyme A reductase on coenzyme Q and dolichol biosynthesis.

E L Appelkvist et al.

The Clinical investigator, 71(8 Suppl), S97-102 (1993-01-01)

Inhibitors of hydroxymethylglutaryl coenzyme A reductase are used clinically to decrease blood levels of low-density lipoprotein cholesterol in hypercholesterolemic patients. However, little is known about the possible effects of these inhibitors on dolichol and cholesterol synthesis. Oral administration of mevinolin

Effects of treatment with coenzyme Q10 on exercised rat aorta.

N Okudan et al.

Acta physiologica Hungarica, 99(1), 40-50 (2012-03-20)

In this study, the effect of long-term supplementation of coenzyme Q10 (CoQ10) on the responses of swim-trained rat aorta was investigated. Twenty-four adult male Wistar rats were divided into four groups: untrained, trained, untrained+CoQ10, and trained+CoQ10 group. In the trained

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Global Trade Item Number

SKU	GTIN
C9538-100MG	04061833530818
C9538-1G	04061833530825
C9538-500MG	04061833530832