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D134

3,7-Dimethyl-1-propargylxanthine

Name: 3,7-Dimethyl-1-propargylxanthine
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

3,7-Dimethyl-1-(2-propynyl)xanthine, DMPX

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₀N₄O₂

CAS Number:

14114-46-6

Molecular Weight:

218.21

NACRES:

NA.77

PubChem Substance ID:

24277754

UNSPSC Code:

12352200

MDL number:

MFCD00078576

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 15 mg/mL, clear

SMILES string

CN1C(=O)N(CC#C)C(=O)c2c1ncn2C

InChI

1S/C10H10N4O2/c1-4-5-14-9(15)7-8(11-6-12(7)2)13(3)10(14)16/h1,6H,5H2,2-3H3

InChI key

IORPOFJLSIHJOG-UHFFFAOYSA-N

Gene Information

human ... ADORA2A(135), ADORA2B(136)
rat ... Adora1(29290), Adora2a(25369)

Description

Application

3,7-Dimethyl-1-propargylxanthine (DMPX) has been used as an A₂ -adenosine receptor (AR) antagonist:

to study its effects on potential modulation of motor output elicited by epidural spinal stimulation (ESS)
to study the role of A_2areceptor in elevating cyclic adenosine monophosphate (cAMP) levels
to study its effects on the cell viability of human gastric cancer cell line

Biochem/physiol Actions

3,7-Dimethyl-1-propargylxanthine (DMPX) is a caffeine analog and A₂-selective adenosine receptor (AR) antagonist.

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Characterization of the potency, selectivity, and pharmacokinetic profile for six adenosine A2A receptor antagonists.

Ming Yang et al.

Naunyn-Schmiedeberg's archives of pharmacology, 375(2), 133-144 (2007-02-21)

Antagonists of adenosine A2A receptors (A2A -antagonists) with different chemical structures have been developed by several pharmaceutical companies for the potential treatment of Parkinson's disease. Pharmacological characterization of these antagonists was incomplete, and different assay conditions were used in different

Single-residue changes in the C-terminal disulfide-bonded loop of the Pseudomonas aeruginosa type IV pilin influence pilus assembly and twitching motility.

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Journal of bacteriology, 191(21), 6513-6524 (2009-09-01)

PilA, the major pilin subunit of Pseudomonas aeruginosa type IV pili (T4P), is a principal structural component. PilA has a conserved C-terminal disulfide-bonded loop (DSL) that has been implicated as the pilus adhesinotope. Structural studies have suggested that DSL is

Adenosine Receptor Stimulation Improves Glucocorticoid-Induced Osteoporosis in a Rat Model.

Gabriele Pizzino et al.

Frontiers in pharmacology, 8, 558-558 (2017-09-21)

Glucocorticoid-induced osteoporosis (GIO) is a secondary cause of bone loss. Bisphosphonates approved for GIO, might induce jaw osteonecrosis; thus additional therapeutics are required. Adenosine receptor agonists are positive regulators of bone remodeling, thus the efficacy of adenosine receptor stimulation for

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Global Trade Item Number

SKU	GTIN
D134-25MG	04061832090276
D134-100MG	04061832090252
D134-10MG	04061833559505