D3648
Diamide
Synonym(s):
1,1′-Azobis(N,N-dimethylformamide), N,N,N′,N′-Tetramethylazodicarboxamide, Azodicarboxylic acid bis(dimethylamide), Diazenedicarboxylic acid bis(N,N-dimethylamide), TMAD
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About This Item
Linear Formula:
(CH3)2NCON=NCON(CH3)2
CAS Number:
Molecular Weight:
172.19
UNSPSC Code:
12352102
NACRES:
NA.22
PubChem Substance ID:
EC Number:
233-951-7
Beilstein/REAXYS Number:
1910409
MDL number:
assay
≥98% (TLC)
Quality Level
form
powder
mp
113-115 °C
solubility
water: 19.60-21.00 mg/mL, clear to slightly hazy, orange
storage temp.
−20°C
SMILES string
CN(C)C(=O)\N=N\C(=O)N(C)C
InChI
1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+
InChI key
VLSDXINSOMDCBK-BQYQJAHWSA-N
Application
Reported to be of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Treatment increased protein glutathiolation in a concentration-dependent manner and had comparably little effect on protein-protein disulfide formation.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Bradford G Hill et al.
Biochimica et biophysica acta, 1797(2), 285-295 (2009-11-21)
Protein thiolation by glutathione is a reversible and regulated post-translational modification that is increased in response to oxidants and nitric oxide. Because many mitochondrial enzymes contain critical thiol residues, it has been hypothesized that thiolation reactions regulate cell metabolism and
Carlos A Sorgi et al.
Scientific reports, 7(1), 10981-10981 (2017-09-10)
The differentiation of resident tissue macrophages from embryonic precursors and that of inflammatory macrophages from bone marrow cells leads to macrophage heterogeneity. Further plasticity is displayed through their ability to be polarized as subtypes M1 and M2 in a cell
Toshifumi Nakao et al.
Insect biochemistry and molecular biology, 43(4), 366-375 (2013-02-19)
The RDL GABA receptor is an attractive target of insecticides. Here we demonstrate that meta-diamides [3-benzamido-N-(4-(perfluoropropan-2-yl)phenyl)benzamides] are a distinct class of RDL GABA receptor antagonists showing high insecticidal activity against Spodoptera litura. We also suggest that the mode of action
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D3648-5G | 04061833563403 |
| D3648-1G | 04061833563397 |