D3900
Desipramine hydrochloride
≥98% (TLC), powder, imipramine metabolite
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C18H22N2 · HCl
CAS Number:
Molecular Weight:
302.84
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
200-373-1
MDL number:
Product Name
Desipramine hydrochloride, ≥98% (TLC), powder
Quality Level
assay
≥98% (TLC)
form
powder
color
white to off-white
solubility
H2O: 50 mg/mL
originator
Sanofi Aventis
storage temp.
2-8°C
SMILES string
Cl[H].CNCCCN1c2ccccc2CCc3ccccc13
InChI
1S/C18H22N2.ClH/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20;/h2-5,7-10,19H,6,11-14H2,1H3;1H
InChI key
XAEWZDYWZHIUCT-UHFFFAOYSA-N
Gene Information
human ... SLC6A2(6530)
General description
Desipramine, a metabolite of imipramine and iofepramine is an active tricyclic antidepressant.
Application
Desipramine hydrochloride has been used:
- to prevent norepinephrine neuron degeneration and to maximize uptake into DA neurons
- to protect unselective damage to the noradrenergic system
- as a norepinephrine re-uptake inhibitor to treat rats for lesioning
Biochem/physiol Actions
Desipramine is used to treat depression. It is also used to manage enuresis in children. Desipramine helps to eliminate the pain triggered by diabetic neuropathy.
Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (Ki = 4 nM) than the serotonin transporter (Ki = 61 nM).
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Disclaimer
Hygroscopic
Still not finding the right product?
Explore all of our products under Desipramine hydrochloride
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy
Max M B, et al.
The New England Journal of Medicine, 326(19), 1250-1256 (1992)
Desipramine
reference module in biomedical sciences (2018)
Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation
Li S, et al.
Journal of Neurophysiology (2007)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D3900-1G | 04061835253166 |
| D3900-25G | 04061835253173 |
| D3900-5G | 04061833563694 |