D4010
2′-Deoxyguanosine 5′-triphosphate sodium salt hydrate
≥96% (HPLC), synthetic (organic), powder
Synonym(s):
2′-deoxy-, 5′-triphosphate sodium salt, Guanosine, dGTP sodium salt hydrate
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About This Item
Empirical Formula (Hill Notation):
C10H16N5O13P3 · xNa+ · yH2O
CAS Number:
Molecular Weight:
507.18 (anhydrous free acid basis)
MDL number:
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
Assay:
≥96% (HPLC)
Biological source:
synthetic (organic)
Form:
powder
Storage temp.:
−20°C
Product Name
2′-Deoxyguanosine 5′-triphosphate sodium salt hydrate, ≥96% (HPLC)
biological source
synthetic (organic)
Quality Level
assay
≥96% (HPLC)
form
powder
shipped in
dry ice
storage temp.
−20°C
Application
2′-Deoxyguanosine 5′-triphosphate sodium salt hydrate has been used:
- as a component in a polymerase chain reaction (PCR) mixture for PCR product formation using AM-toxin primers
- as an internal standard to improve the analytical performance of capillary electrophoresis (CE) analysis for the evaluation of the cleanup process
- as a putative substrate in in vitro enzyme activity assay to incubate with nudix hydrolase 15 (NUDT15) protein for the evaluation of putative NUDT15 inhibitors
Biochem/physiol Actions
Deoxyguanosine 5′-triphosphate (dGTP), a purine deoxynucleotide, is a substrate of DNA polymerase(s) and reverse transcriptases. dGTP is useful to study the distribution, specificity, and kinetics of various nucleoside-triphosphatases (NTPase) and ribonucleotide reductases.
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
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Yogesh A Karpe et al.
PloS one, 6(7), e22336-e22336 (2011-08-04)
Chikungunya virus (CHIKV) is an insect borne virus (genus: Alphavirus) which causes acute febrile illness in humans followed by a prolonged arthralgic disease that affects the joints of the extremities. Re-emergence of the virus in the form of outbreaks in
Yimon Aye et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(24), 9815-9820 (2011-06-02)
Human ribonucleotide reductases (hRNRs) catalyze the conversion of nucleotides to deoxynucleotides and are composed of α- and β-subunits that form active α(n)β(m) (n, m = 2 or 6) complexes. α binds NDP substrates (CDP, UDP, ADP, and GDP, C site)
Si Min Zhang et al.
Cell chemical biology, 28(12), 1693-1702 (2021-07-01)
Ganciclovir (GCV) is the first-line therapy against human cytomegalovirus (HCMV), a widespread infection that is particularly dangerous for immunodeficient individuals. Closely resembling deoxyguanosine triphosphate, the tri-phosphorylated metabolite of GCV (GCV-TP) is preferentially incorporated by the viral DNA polymerase, thereby terminating
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D4010-100MG | 04061833563847 |
| D4010-10MG | 04061833006856 |
| D4010-1G | 04061826690550 |