Key Documents

View All Documentation

D4268

N^G,N^G-Dimethylarginine dihydrochloride

Name: NG,NG-Dimethylarginine dihydrochloride
Brand: SIGMA

≥98% (TLC), powder, NOS inhibitor

Synonym(s):

asym-Dimethylarginine, ADMA

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₈H₁₈N₄O₂ · 2HCl

CAS Number:

220805-22-1

Molecular Weight:

275.18

UNSPSC Code:

12352209

PubChem Substance ID:

24278027

NACRES:

NA.77

MDL number:

MFCD00270857

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

N^G,N^G-Dimethylarginine dihydrochloride,

assay

≥98% (TLC)

Quality Level

200

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

Cl[H].Cl[H].CN(C)C(=N)NCCC[C@H](N)C(O)=O

InChI

1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1

InChI key

SYLNVYJOPZWPJI-ILKKLZGPSA-N

Gene Information

human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

Description

General description

N^G,N^G-Dimethylarginine dihydrochloride is a methylated arginine derivative, which is produced by the liver. It is linked to liver cirrhosis, alcoholic hepatitis and acute liver failure (ALF).

Application

N^G,N^G- Dimethylarginine dihydrochloride has been used:

to study its effects on cardiovascular activities in rostral ventrolateral medulla (RVLM) in rats
as a standard for measuring L-arginine and dimethylarginines
to study its effects on hepatic deterioration

Biochem/physiol Actions

Reversible inhibitor of nitric oxide synthetase in vivo and in vitro.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Impact of Treatment Modality on Vascular Function in Coarctation of the Aorta: The LOVE - COARCT Study.

José D Martins et al.

Journal of the American Heart Association, 8(7), e011536-e011536 (2019-04-02)

Background Optimally treated patients with coarctation of the aorta remain at risk for late vascular dysfunction. The effect of treatment modality on vascular function is unknown. The LOVE-COARCT (Long-term Outcomes and Vascular Evaluation After Successful Coarctation of the Aorta Treatment)

Effect of rosuvastatin on fasting and postprandial endothelial biomarker levels and microvascular reactivity in patients with type 2 diabetes and dyslipidemia: a preliminary report.

Kyoung Min Kim et al.

Cardiovascular diabetology, 16(1), 146-146 (2017-11-11)

The cardiovascular benefits of statins have been proven, but their effect on circulation in small vessels has not been examined fully. We investigated the effect of 20 mg rosuvastatin on biomarkers, including paraoxonase-1 (PON-1) and asymmetric dimethylarginine (ADMA), and on microvascular

Effects of prostacyclin on the early inflammatory response in patients with traumatic brain injury-a randomised clinical study.

Marie Rodling Wahlström et al.

SpringerPlus, 3, 98-98 (2014-03-07)

A prospective, randomised, double-blinded, clinical trial was performed at a level 1 trauma centre to determine if a prostacyclin analogue, epoprostenol (Flolan®), could attenuate systemic inflammatory response in patients with severe traumatic brain injury (TBI). 46 patients with severe TBI

View All Related Papers

Global Trade Item Number

SKU	GTIN
D4268-50MG	04061833564233
D4268-10MG	04061833564226