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D8040

(±)-trans-U-50488 methanesulfonate salt

Name: (±)-<I>trans</I>-U-50488 methanesulfonate salt
Brand: SIGMA

Synonym(s):

trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate salt, U-50488H

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₆Cl₂N₂O · CH₄O₃S

Molecular Weight:

465.43

NACRES:

NA.77

PubChem Substance ID:

24278070

UNSPSC Code:

12352106

MDL number:

MFCD00133867

Form:

powder

Quality level:

200

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Properties

form

powder

Quality Level

200

solubility

H₂O: 50 mg/mL

storage temp.

2-8°C

SMILES string

CS(O)(=O)=O.CN([C@@H]1CCCC[C@H]1N2CCCC2)C(=O)Cc3ccc(Cl)c(Cl)c3

InChI

1S/C19H26Cl2N2O.CH4O3S/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;1-5(2,3)4/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1H3,(H,2,3,4)/t17-,18-;/m1./s1

InChI key

OJPHNZCUXUUVKU-JAXOOIEVSA-N

Gene Information

human ... OPRK1(4986)

Description

Application

(±)-trans-U-50488 methanesulfonate salt has been used as a control agonist for κ-opioid receptor.

Biochem/physiol Actions

Selective κ-opioid receptor agonist. (±)-trans-U-50488 methanesulfonate salt is known to induce diuresis. U-50488H is found to prevent morphine tolerance when administered along with it.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain

Basile AS, et al.

Journal of Pharmacology and Experimental Therapeutics, 321(3), 1208-1225 (2007)

Anti-arrhythmic effect of kappa-opioid receptor stimulation in the perfused rat heart: involvement of a cAMP-dependent pathway.

X C Yu et al.

Journal of molecular and cellular cardiology, 31(10), 1809-1819 (1999-10-20)

During myocardial ischaemia the beta-adrenoceptor is activated, which contributes, at least partly, to cardiac arrhythmias via inducing [Ca2+]i oscillations. Since beta-adrenoceptor is negatively modulated by the kappa-opioid receptor in the heart, the present study attempted to determine if kappa-opioid receptor

Pharmacology and Therapeutics in the New Millennium, 462-462 (2001)

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Global Trade Item Number

SKU	GTIN
D8040-100MG	04061833589151
D8040-10MG	04061832862095
D8040-50MG	04061832862101