D9175
Dantrolene sodium salt
Ca2+ release from sarcoplasmic reticulum inhibitor, solid
Synonym(s):
1-[(5-(p-Nitrophenyl)furfurylidene)amino]hydantoin sodium salt
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About This Item
Empirical Formula (Hill Notation):
C14H9N4NaO5
CAS Number:
Molecular Weight:
336.23
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
Quality level:
Product Name
Dantrolene sodium salt,
form
solid
Quality Level
originator
JHP Pharmaceuticals
SMILES string
[Na+].[H]\C(=N/N1CC(=O)N=C1[O-])c2ccc(o2)-c3ccc(cc3)[N+]([O-])=O
InChI
1S/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/q;+1/p-1/b15-7+;
InChI key
KSRLIXGNPXAZHD-HAZZGOGXSA-M
Gene Information
human ... RYR1(6261), RYR3(6263)
Biochem/physiol Actions
Inhibitor of Ca2+ release from sarcoplasmic reticulum; muscle relaxant.
Features and Benefits
This compound is featured on the InsP3/Ryanodine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by JHP Pharmaceuticals. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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G Haskó et al.
British journal of pharmacology, 124(6), 1099-1106 (1998-08-28)
1. Intracellular calcium has been suggested to be an important mediator of the cellular response in endotoxaemia and shock. Dantrolene is an agent that interferes with intracellular calcium fluxes resulting in a decreased availability of calcium in the cytoplasm. Here
Mohammed Ali Azam et al.
Heart rhythm O2, 2(6Part B), 733-741 (2022-01-07)
Doxorubicin (Dox) is a potent chemotherapeutic agent, but its usage is limited by dose-dependent cardiotoxicity. Intracellular calcium dysregulation has been reported to be involved in doxorubicin-induced cardiomyopathy (DICM). The cardioprotective role of RyR stabilizer dantrolene (Dan) on the calcium dynamics
Jiao Liu et al.
Frontiers in pharmacology, 13, 882198-882198 (2022-05-07)
Diabetic cardiomyopathy (DCM) is a serious complication of diabetes that can lead to heart failure and death, for which there is no effective treatment. Rhynchophylline (Rhy) is the main effective component of the Chinese herbal medicine Uncaria rhynchophylla, which mainly
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D9175-100MG | 04061833590478 |
| D9175-1G | 04061826738443 |
| D9175-250MG | 04061833590485 |