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E1894

EPPS

Name: EPPS
Brand: SIGMA

BioXtra, ≥99.5% (titration)

Synonym(s):

Triethanolamine hydrochloric acid salt, 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid, 4-(2-Hydroxyethyl)piperazine-1-propanesulfonic acid, N-(2-Hydroxyethyl)piperazine-N′-(3-propanesulfonic acid), HEPPS

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About This Item

Empirical Formula (Hill Notation):

C₉H₂₀N₂O₄S

CAS Number:

16052-06-5

Molecular Weight:

252.33

UNSPSC Code:

12161700

NACRES:

NA.25

PubChem Substance ID:

24894443

EC Number:

240-198-8

Beilstein/REAXYS Number:

3957385

MDL number:

MFCD00006160

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Properties

product line

BioXtra

Quality Level

400

assay

≥99.5% (titration)

form

powder

impurities

≤0.005% Phosphorus (P), ≤0.1% Insoluble matter

ign. residue

≤0.1%

pH

5.0-7.0 (20 °C, 1 M in H₂O)

useful pH range

7.3-8.7

pKa

mp

237-239 °C (lit.)

solubility

H₂O: 1 M at 20 °C, clear, colorless

anion traces

bromide (Br^-): ≤0.1%

cation traces

Al: ≤0.0005%, Ca: ≤0.002%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, NH₄⁺: ≤0.1%, Na: ≤0.005%, Pb: ≤0.001%, Zn: ≤0.0005%

absorption

≤0.1 at 260 in H₂O at 1 M, ≤0.1 at 280 in H₂O at 1 M

application(s)

diagnostic assay manufacturing

SMILES string

OCCN1CCN(CCCS(O)(=O)=O)CC1

InChI

1S/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15)

InChI key

OWXMKDGYPWMGEB-UHFFFAOYSA-N

Description

General description

EPPS, also known as 4-(2-hydroxyethyl)piperazine-1-propanesulfonic acid, is a zwitterionic buffering agent that belongs to the group of good buffers. It plays a vital role in maintaining a stable pH in solutions, which is critical for various biological and biochemical processes. EPPS buffer finds extensive application in biological research and cell culture experiments.

Application

EPPS buffer has been used as a component of buffer solution for methylglyoxal (MG) treatment in vitro to form advanced glycation end products (AGEs) to crosslink collagen fibrils. It has also been used in the preparation of fixation buffer solution for light microscopy.

Features and Benefits

The BioXtra product line ensures T15 high-quality products for consistent results.
A high assay of ≥99.5% guarantees the purity of the product.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques.

Hye Yun Kim et al.

Nature communications, 6, 8997-8997 (2015-12-10)

Alzheimer's disease (AD) is characterized by the transition of amyloid-β (Aβ) monomers into toxic oligomers and plaques. Given that Aβ abnormality typically precedes the development of clinical symptoms, an agent capable of disaggregating existing Aβ aggregates may be advantageous. Here

GPR4 decreases B16F10 melanoma cell spreading and regulates focal adhesion dynamics through the G13/Rho signaling pathway.

Calvin R Justus et al.

Experimental cell research, 334(1), 100-113 (2015-04-08)

The effect of acidosis, a biochemical hallmark of the tumor microenvironment, on cancer progression and metastasis is complex. Both pro- and anti-tumorigenic effects of acidosis have been reported and the acidic microenvironment has been exploited for specific delivery of drugs

The infiltration and functional regulation of eosinophils induced by TSLP promote the proliferation of cervical cancer cell.

Feng Xie et al.

Cancer letters, 364(2), 106-117 (2015-05-17)

Cervical cancer is often associated with eosinophil (EOS) infiltration, but the source and the role of EOS are still largely unknown. Our previous work has established that thymic stromal lymphopoietin (TSLP) can stimulate the growth of cervical cancer cell in

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Global Trade Item Number

SKU	GTIN
E1894-100G	04061833610718
E1894-1KG	04061833602270
E1894-250G	04061833610725
E1894-25G	04061833602287