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F6020

Fenofibrate

Name: Fenofibrate
Brand: SIGMA

≥99% (TLC), powder, PPARα agonist

Synonym(s):

2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₁ClO₄

CAS Number:

49562-28-9

Molecular Weight:

360.83

NACRES:

NA.77

PubChem Substance ID:

24278015

UNSPSC Code:

12352200

EC Number:

256-376-3

MDL number:

MFCD00133314

Assay:

≥99%

Form:

powder

Quality level:

100

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Properties

Product Name

Fenofibrate, ≥99%, powder

Quality Level

100

assay

≥99%

form

powder

color

off-white

originator

Abbott

storage temp.

room temp

SMILES string

CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(Cl)cc2

InChI

1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3

InChI key

YMTINGFKWWXKFG-UHFFFAOYSA-N

Gene Information

human ... PPARA(5465)

Description

Application

Fenofibrate has been used:

to study its effect on plasma lipids, liver phenotype and gene expression
to study its impact on endothelium-dependent vasodilatation of thoracic aorta
to administer to NASH knock-in mice along with a high fat diet (HFD) to study its effect

Biochem/physiol Actions

Fenofibrate increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expression. It is used in treating the condition of increased cholesterol levels in the blood, abnormal lipid levels in the body and also hypertriglyceridaemia. Fenofibrate is a lipid regulating drug and proliferator-activated receptor-α (PPARα) mediates its action. It decreases the plasma levels of fibrinogen and C-reactive protein. By this fenofibrate allows better flow-mediated dilatation and reduces the risk of atherosclerosis. Fenofibrate is also known to reduce uric acid levels.

Features and Benefits

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS08

signalword

Warning

hcodes

H373

pcodes

P260 - P314 - P501

Hazard Classifications

STOT RE 2 Oral

target_organs

Liver

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Articles

胆固醇的运输

由于胆固醇是水不溶性分子，必须包装后才能在血浆中运输。包装胆固醇、胆固醇酯和甘油三酯以便运输的颗粒称为脂蛋白。

Discover Bioactive Small Molecules for Lipid Signaling Research

Cholesterol Transport

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

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Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates

Shiri-Sverdlov R, et al.

Journal of Hepatology, 44(4), 732-741 (2006)

Fenofibrate

Keating GM and Croom KF

Drugs, 67(1), 121?153-121?153 (2012)

Profiling sensory neuron microenvironment after peripheral and central axon injury reveals key pathways for neural repair.

Oshri Avraham et al.

eLife, 10 (2021-09-30)

Sensory neurons with cell bodies in dorsal root ganglia (DRG) represent a useful model to study axon regeneration. Whereas regeneration and functional recovery occurs after peripheral nerve injury, spinal cord injury or dorsal root injury is not followed by regenerative

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Global Trade Item Number

SKU	GTIN
F6020-25G	04061833618417
F6020-100G	04061833057629
F6020-5G	04061833618424

Key Documents

Fenofibrate

≥99% (TLC), powder, PPARα agonist

Select a Size

About This Item

Product Name

Quality Level

assay

form

color

originator

storage temp.

SMILES string

InChI

InChI key

Gene Information

Application

Biochem/physiol Actions

Features and Benefits

Still not finding the right product?

Safety Information

pictograms

signalword

hcodes

pcodes

Hazard Classifications

target_organs

Storage Class

wgk

flash_point_f

flash_point_c

ppe

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Protocols and Articles

Articles

Peer Reviewed Papers

Global Trade Item Number