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F7131

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly

Name: N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly
Brand: SIGMA

chromogenic, ≥99% (HPLC)

Synonym(s):

FAPGG, N-[3-(2-Furyl)acryloyl]-L-phenylalanyl-glycyl-glycine

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₁N₃O₆

CAS Number:

64967-39-1

Molecular Weight:

399.40

UNSPSC Code:

12352202

PubChem Substance ID:

24894929

NACRES:

NA.32

MDL number:

MFCD00036816

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Properties

Product Name

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly,

Quality Level

300

storage temp.

−20°C

SMILES string

OC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)\C=C\c2ccco2

InChI

1S/C20H21N3O6/c24-17(9-8-15-7-4-10-29-15)23-16(11-14-5-2-1-3-6-14)20(28)22-12-18(25)21-13-19(26)27/h1-10,16H,11-13H2,(H,21,25)(H,22,28)(H,23,24)(H,26,27)/b9-8+/t16-/m0/s1

InChI key

ZDLZKMDMBBMJLI-FDMDGMSGSA-N

Gene Information

human ... ACE(1636), ACE2(59272)
mouse ... ACE3(217246)
rat ... ACE(11421), ACE2(70008), ACE3(498012)

Description

General description

A substrate for continuous spectrophotometric assay of angiotensin converting enzyme (ACE).

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly acts as a substrate for angiotensin converting enzyme (ACE), and is used in inhibitory assays of ACE.

Application

N-[3-(2-Furyl)acryloyl]-Phe-Gly-Gly has been used for kinetic spectrophotometric assay of ACE (angiotensin converting enzyme) inhibitory activity.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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A multiple biomarker assay for quality assessment of botanical drugs using a versatile microfluidic chip.

Zhen-Hao Li et al.

Scientific reports, 7(1), 12243-12243 (2017-09-28)

Quality control is critical for ensuring the safety and effectiveness of drugs. Current quality control method for botanical drugs is mainly based on chemical testing. However, chemical testing alone may not be sufficient as it may not capture all constituents

Evaluation of anti-hypertensive activity of Ulmus wallichiana extract and fraction in SHR, DOCA-salt- and L-NAME-induced hypertensive rats.

Anees A Syed et al.

Journal of ethnopharmacology, 193, 555-565 (2016-10-11)

Ulmus wallichiana Planchon (Himalayan Elm), a traditional medicinal plant, used in fracture healing in folk tradition of Uttarakhand, Himalaya, India. It is also used as diuretic. U. rhynchophylla, native to China, known as Gou Teng in Chinese medicine, is used

Identification of new polymorphisms of the angiotensin I-converting enzyme (ACE) gene, and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis.

E Villard et al.

American journal of human genetics, 58(6), 1268-1278 (1996-06-01)

Plasma angiotensin I-converting enzyme (ACE) levels are highly genetically determined. A previous segregation-linkage analysis suggested the existence of a functional mutation located within or close to the ACE locus, in almost complete linkage desequilibrium (LD) with the ACE insertion/deletion (I/D)

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Global Trade Item Number

SKU	GTIN
F7131-25MG	04061833619308
F7131-100MG	04061833619292
F7131-500MG	04061833619315