G1796
Glycolide
≥99%
Synonym(s):
1,4-Dioxane-2,5-dione
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About This Item
Empirical Formula (Hill Notation):
C4H4O4
CAS Number:
Molecular Weight:
116.07
NACRES:
NA.23
PubChem Substance ID:
UNSPSC Code:
12162002
EC Number:
207-954-9
MDL number:
Quality Level
assay
≥99%
mp
82-86 °C (lit.)
shipped in
dry ice
storage temp.
−20°C
SMILES string
O=C1COC(=O)CO1
InChI
1S/C4H4O4/c5-3-1-7-4(6)2-8-3/h1-2H2
InChI key
RKDVKSZUMVYZHH-UHFFFAOYSA-N
General description
Glycolide is a cyclic dimer of α-hydroxy acid that can be used in the formation of aliphatic polyester. It is synthesized by the dimerization of glycolic acid. It forms a low toxic synthetic biodegradable polymer that can be used in medical applications. It is majorly used in the formation of a highly crystalline poly(glycolide) by ring opening polymerization.
Application
Glycolide can be used as a monomer in the preparation of poly(lactic-co-glycolide)(PGLA) via copolymerization with lactide monomer. PGLA is further used in the following applications:
- Porous PGLA microsphere scaffolds are used in bone repair applications.
- Encapsulated PGLA nanoparticles can be used in drug delivery and tissue engineering applications. Polymeric micro/nanoparticles made from PLGA have gained significant interest for their appealing characteristics, including biodegradability, biocompatibility, prolonged drug release, and safeguarding the drug against degradation.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Towards electroactive gel artificial muscle structures
Electroactive Polymer Actuators and Devices (EAPAD) XX, 10594, 1059408-1059408 (2018)
Types of biodegradable polymers
Introduction of Bioplastic Engineering, 81-151 (2016)
J L Guo et al.
Science advances, 5(6), eaaw7396-eaaw7396 (2019-06-12)
Synthetic hydrogels are investigated extensively in tissue engineering for their tunable physicochemical properties but are bioinert and lack the tissue-specific cues to produce appropriate biological responses. To introduce tissue-specific biochemical cues to these hydrogels, we have developed a modular hydrogel
Global Trade Item Number
| SKU | GTIN |
|---|---|
| G1796-25G | 04061833628409 |