G2128
L-Glutamic acid hydrochloride
≥99% (HPLC), kainate, NMDA, and quisqualate agonist
Synonym(s):
(S)-2-Aminoglutaric acid, (S)-2-Aminopentanedioic acid ammonium salt, Glu HCl
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About This Item
Empirical Formula (Hill Notation):
C5H9NO4 · HCl
CAS Number:
Molecular Weight:
183.59
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
205-315-9
MDL number:
Beilstein/REAXYS Number:
3565569
Product Name
L-Glutamic acid hydrochloride, ≥99% (HPLC)
Quality Level
assay
≥99% (HPLC)
SMILES string
Cl.N[C@@H](CCC(O)=O)C(O)=O
InChI
1S/C5H9NO4.ClH/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);1H/t3-;/m0./s1
InChI key
RPAJSBKBKSSMLJ-DFWYDOINSA-N
Gene Information
human ... GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901)
General description
L-glutamate is the major excitatory neurotransmitter in mammalian central nervous system (CNS). It interacts with membrane bound glutamate receptors.
Application
L-Glutamic acid hydrochloride has been used as a nutrient additive to study the effect of increased dissolved inorganic nitrogen (DIN) on the uptake of dissolved organic nitrogen (DON) and dissolved organic carbon (DOC), in a nitrogen-limited headwater forest stream.
Biochem/physiol Actions
Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.
L-glutamate plays key roles in development, learning, memory, plasticity and cognition. It plays crucial role in the pathogenesis of neuropathological diseases such as epilepsy, schizophrenia, stroke, ischemia, ALS (amyotrophic lateral sclerosis), Huntington′s disease and Parkinson′s disease. Glutamate is also responsible for the activation of long-term potentiation (LTP) and long-term depression (LTD). Induction of glutamate receptors plays a key role in the pathophysiology of migraine.
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signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Related Content
Coupled cycling of dissolved organic nitrogen and carbon in a forest stream.
Brookshire E N J et al
Ecology, 86(9), 2487-2496 (2005)
Martina Curto et al.
The journal of headache and pain, 17, 47-47 (2016-05-01)
Activation of glutamate (Glu) receptors plays a key role in the pathophysiology of migraine. Both NMDA and metabotropic Glu receptors are activated or inhibited by metabolites of the kynurenine pathway, such as kynureninic acid (KYNA), quinolinic acid (QUINA), and xanthurenic
B K Day et al.
Journal of neurochemistry, 96(6), 1626-1635 (2006-01-31)
L-glutamate (Glu) is the predominant excitatory neurotransmitter in the mammalian central nervous system. It plays major roles in normal neurophysiology and many brain disorders by binding to membrane-bound Glu receptors. To overcome the spatial and temporal limitations encountered in previous
Global Trade Item Number
| SKU | GTIN |
|---|---|
| G2128-100G | 04061833628614 |
| G2128-1KG | 04061826744796 |
| G2128-500G | 04061833007242 |