G3643
α1-Acid Glycoprotein from bovine plasma
≥99%
Synonym(s):
Orosomucoid
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About This Item
Form:
powder
Assay:
≥99%
Biological source:
bovine plasma
biological source
bovine plasma
Quality Level
assay
≥99%
form
powder
technique(s)
electrophoresis: suitable, mass spectrometry (MS): suitable
UniProt accession no.
storage temp.
2-8°C
Gene Information
bovine ... ORM1(497200)
General description
α1-Acid Glycoprotein (AGP, orosomucoid) from bovine plasma belongs to ‘lipocalins′ family which binds and transports small hydrophobic molecules. AGP is further classified into the subfamily ‘immunocalins′ which immunomodulates the inflammatory reactions. AGP is primarily produced in the liver, in few extra hepatic tissues and is present in neutrophil granules. Healthy cattle possesses 0.3 mg of AGP/ ml of concentrated serum.
α1-Acid glycoprotein (AGP, orosomucoid) is the major plasma glycoprotein with a molecular weight of 41-43 kDa. It is responsible for possessing the complex type of glycans.
Application
α1-Acid Glycoprotein (AGP) from bovine plasma has been used:
- in mass spectrometry analysis to confirm the presence of Neu5Ac and Neu5Gc distribution in human and bovine AGP respectively
- for pretreating the microvessel before perfusing the MDA-MB-231 cells for tumor adhesion studies
- in the composition of tear model
- as a reference in sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)
α1-Acid glycoprotein was used to study nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine
Biochem/physiol Actions
α1-Acid Glycoprotein from bovine plasma is an acute phase protein. It has anti-inflammatory potential and its concentration increases several folds during injury. AGP increases the chemotactic activity and life span of monocytes and inhibits neutrophil degranulation. Serum AGP levels differentiates sepsis from systemic inflammatory response syndrome (SIRS).
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Storage Class
13 - Non Combustible Solids
Regulatory Information
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Articles
PNGase Fast denaturing buffer and enzyme provide results similar to a conventional 20-hour protocol, reducing workflow time to about 1 hour.
alpha1-Acid glycoprotein modulates phagocytosis and killing of Escherichia coli by bovine polymorphonuclear leucocytes and monocytes
Lecchi C, et al.
The Veterinary Journal, 196(1), 47-51 (2013)
Adhesion of malignant mammary tumor cells MDA-MB-231 to microvessel wall increases microvascular permeability via degradation of endothelial surface glycocalyx
Cai B, et al.
Journal of Applied Physiology, 113(7), 1141-1153 (2012)
Mohamed F AlAjmi et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 225, 117457-117457 (2019-08-27)
Drug-binding and interactions with plasma proteins strongly affect their efficiency of delivery, hence considered as a key factor in determining the overall pharmacological action. Alpha-1-acid glycoprotein (AGP), a second most abundant plasma protein in blood circulation, has unique drug binding
Global Trade Item Number
| SKU | GTIN |
|---|---|
| G3643-100MG | 04061833271209 |
| G3643-250MG | 04061833630044 |
| G3643-25MG | 04061833630051 |