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G5386

Gly-Gly-Tyr-Arg

Name: Gly-Gly-Tyr-Arg
Brand: SIGMA

powder, ≥97% (HPLC)

Synonym(s):

GGYR, Glycyl-glycyl-tyrosyl-arginine

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₉N₇O₆

CAS Number:

70195-20-9

Molecular Weight:

451.48

UNSPSC Code:

12352204

PubChem Substance ID:

24895206

NACRES:

NA.83

MDL number:

MFCD00076760

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Properties

Product Name

Gly-Gly-Tyr-Arg, ≥97% (HPLC)

biological source

synthetic (organic)

Quality Level

200

assay

≥97% (HPLC)

form

powder

solubility

water: 2 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

NCC(=O)NCC(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CCCNC(N)=N)C(O)=O

InChI

1S/C19H29N7O6/c20-9-15(28)24-10-16(29)25-14(8-11-3-5-12(27)6-4-11)17(30)26-13(18(31)32)2-1-7-23-19(21)22/h3-6,13-14,27H,1-2,7-10,20H2,(H,24,28)(H,25,29)(H,26,30)(H,31,32)(H4,21,22,23)

InChI key

FJPHHBGPPJXISY-UHFFFAOYSA-N

Description

Application

Gly-Gly-Tyr-Arg has been used:

in the synthesis of the dimethoxyphosphotyrosine adduct to determine if diethoxyphosphate tyrosine (depY), a monoclonal antibody could distinguish between dimethoxyphosphotyrosine and diethoxyphosphotyrosine
to graft on to a soft polyacrylamide for sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE) to perform high-resolution separation of peptides
as a model peptide to react with 3,3-dithiobis(sulfosuccinimidyl propionate) (DTSSP) to understand the chemistry of DTSSP and similar cross-linking reagents

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Neutrophils convert tyrosyl residues in albumin to chlorotyrosine.

A J Kettle

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Hypochlorous acid chlorinates tyrosyl residues in small peptides to produce chlorotyrosine. Detection of chlorotyrosine has the potential to unequivocally identify the contribution hypochlorous acid makes to inflammation. I have developed a selective and sensitive HPLC assay for measuring chlorotyrosine. When

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N Belcheva et al.

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Maryse Bonnin-Jusserand et al.

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Global Trade Item Number

SKU	GTIN
G5386-100MG	04061833261866