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Merck
CN

G5889

L-Glutamic acid monosodium salt hydrate

BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99%

Synonym(s):

(S)-2-Aminopentanedioic acid, L-Glutamic acid monosodium salt, Glu, MSG, Monosodium glutamate

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About This Item

Empirical Formula (Hill Notation):
C5H8NNaO4 · xH2O
CAS Number:
Molecular Weight:
169.11 (anhydrous basis)
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
EC Number:
205-538-1
NACRES:
NA.75
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product line

BioReagent

Quality Level

assay

≥99%

form

powder

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable

color

white to off-white

mp

163 °C

SMILES string

[NaH].NC(CCC(=O)O)C(=O)O.O

InChI

1S/C5H9NO4.Na.H2O.H/c6-3(5(9)10)1-2-4(7)8;;;/h3H,1-2,6H2,(H,7,8)(H,9,10);;1H2;

InChI key

JYDGDQPVBSBYRT-UHFFFAOYSA-N

General description

L-Glutamic acid/monosodium glutamate (MSG) is the sodium salt of glutamic acid. It is a commonly used food additive.

Application

L-Glutamic acid monosodium salt hydrate has been used:
  • to prepare glutamate stock solution in HEPES-buffered saline (HBS) for glutamate perfusions
  • as a component in YNG (yeast nitrogen base glutamate) medium
  • used to treat HT22 hippocampal cells to study its effects on cell viability and to examine the expression of molecules related to apoptotic cell death
  • as a component of fresh media to culture neurons and to assess glutamate uptake

Biochem/physiol Actions

Monosodium glutamate (MSG) is a food additive and an environmental agent, that can affect inflammation.
Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.


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Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Monosodium glutamate (MSG): a villain and promoter of liver inflammation and dysplasia
Nakanishi Y, et al.
Journal of Autoimmunity, 30(1-2), 42-50 (2008)
Single-step marker switching in Schizosaccharomyces pombe using a lithium acetate transformation protocol
Brown S D and Lorenz A
Bio-protocol, 6(24) (2016)
Neuroprotective effects of 2, 3, 5, 4?-tetrahydoxystilbene-2-O-beta-D-glucoside from Polygonum multiflorum against glutamate-induced oxidative toxicity in HT22 cells
Lee S Y, et al.
Journal of Ethnopharmacology, 195, 64-70 (2017)



Global Trade Item Number

SKUGTIN
G5889-500G04061833638651
G5889-100G04061833638637
G5889-1KG04061833638644