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G6129

Guanosine 3′,5′-cyclic monophosphate sodium salt

Name: Guanosine 3&#8242;,5&#8242;-cyclic monophosphate sodium salt
Brand: SIGMA

≥99% (HPLC), Cyclic nucleotide, powder

Synonym(s):

3′,5′-Cyclic GMP monosodium salt, 3′,5′-cGMP-Na, Guanosine 3′,5′-cyclophosphate monosodium salt, cGMP, cyclic GMP

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₁N₅NaO₇P

CAS Number:

40732-48-7

Molecular Weight:

367.19

NACRES:

NA.77

PubChem Substance ID:

24895245

UNSPSC Code:

41106305

EC Number:

255-056-0

MDL number:

MFCD00038424

Beilstein/REAXYS Number:

6467425

Assay:

≥99% (HPLC)

Form:

powder

Quality level:

200

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Properties

Product Name

Guanosine 3′,5′-cyclic monophosphate sodium salt, ≥99% (HPLC), powder

Quality Level

200

assay

≥99% (HPLC)

form

powder

color

white

solubility

H₂O: 50 mg/mL

storage temp.

−20°C

SMILES string

[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)C(=O)N1

InChI

1S/C10H12N5O7P.Na/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1

InChI key

KMPIYXNEROUNOG-GWTDSMLYSA-M

Description

Biochem/physiol Actions

An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG).

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases and PKA & PKG pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Global Trade Item Number

SKU	GTIN
G6129-25MG	04061833638859
G6129-500MG	04061832898056
G6129-100MG	04061832898032
G6129-1G	04061826682722
G6129-250MG	04061832898049