G6752
Guanosine
≥98%
Synonym(s):
9-(β-D-Ribofuranosyl)guanine, Guanine-9-β-D-ribofuranoside
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About This Item
Empirical Formula (Hill Notation):
C10H13N5O5
CAS Number:
Molecular Weight:
283.24
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
NACRES:
NA.51
EC Number:
204-227-8
Beilstein/REAXYS Number:
625911
Assay:
≥98%
Biological source:
microbial
Form:
powder
Solubility:
formic acid:water (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
biological source
microbial
Quality Level
assay
≥98%
form
powder
mp
250 °C (dec.) (lit.)
solubility
formic acid:water (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
SMILES string
[H]O[H].NC1=Nc2c(ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1
InChI
1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
InChI key
NYHBQMYGNKIUIF-UUOKFMHZSA-N
General description
Guanosine is an aromatic organic molecule and a purine nucleoside. It is present in the cerebrospinal fluid, intestinal cells, blood-brain barrier and in brain microvessels.
Application
Guanosine has been used:
- as a reference standard for the analysis of glucosinolates by high-performance liquid chromatography with diode-array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI/MS)
- as a component of Mouse Embryonic Fibroblasts (MEFs) culture
- as a standard for the detection of residual RNA contaminant in oil palm plant genome samples by HPLC
Biochem/physiol Actions
Guanosine nucleoside elicits cellular effect as the guanine-based purinergic system. It modulates glutamate uptake by glutamate transporters. It may have neuroprotective functionality in central nervous system disorders. Guanosine promotes neurite arborization, outgrowth, proliferation and differentiation. Administration of guanosine replenished GTP and elicits protective function in renal ischemic injury.
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Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Guanosine: a neuromodulator with therapeutic potential in brain disorders
Lanznaster D, et al.
Aging and disease, 7(5), 657-657 (2016)
mTORC1 couples nucleotide synthesis to nucleotide demand resulting in a targetable metabolic vulnerability
Valvezan AJ, et al.
Cancer Cell, 32(5), 624-638 (2017)
Qualitative and quantitative analysis of glucosinolates and nucleosides in Radix Isatidis by HPLC and liquid chromatography tandem mass spectrometry
Wang X, et al.
Acta Pharmaceutica Sinica. B, 3(5), 337-344 (2013)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| G6752-100G | 04061833640791 |
| G6752-500G | 04061833620564 |
| G6752-1G | 04061833640876 |
| G6752-25G | 04061833640975 |