G8764
Gc-globulin from human plasma
≥90% (SDS-PAGE), lyophilized powder (containing sodium chloride and sodium phosphate buffer salt)
Synonym(s):
DBP, Group-Specific Component, Vitamin D Binding Protein
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About This Item
Form:
lyophilized powder (containing sodium chloride and sodium phosphate buffer salt)
Assay:
≥90% (SDS-PAGE)
Biological source:
human plasma
Mol wt:
~52 kDa
General description
Gc-globulin from human plasma is encoded by the gene GC, which is mapped to human chromosome 4q13.3.
Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.
Gc-globulin or the vitamin D binding protein (DBP) is a 51-58 kDa multifunctional serum glycoprotein synthesized in large quantities by primarily in the liver. It is a member of the albumin gene family and has the characteristic multiple disulfide-bonded, triple domain structure.
Application
Gc-globulin from human plasma has been used:
- as a fluorescent probe for G-actin staining
- as a fluorescent probe to monitor steady-state rate of actin filament disassembly
- as a calibrator for liquid chromatography with mass spectrometry (LC-MS/MS)
Gc-globulin is a multifunctional, albumin-like plasma protein that often requires cell surface binding to mediate some of its diverse functions. It has been used to anlayze its glycosylation patterns.
Biochem/physiol Actions
Single nucleotide polymorphism in the gene GC is associated with deficiency of 25-hydroxyvitamin D [25(OH)D].
Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, a part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.
Preparation Note
Native Gc-globulin from human plasma
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
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Cofilin-2 controls actin filament length in muscle sarcomeres
Kremneva E, et al.
Developmental Cell, 31(2), 215-226 (2014)
Acute homeostatic changes following Vitamin D2 supplementation
Berg AH, et al.
Journal of the Endocrine Society, 1(9), 1135-1149 (2017)
K Jie et al.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 3(3), S145-S147 (1985-12-01)
Effects of exogenous and endogenous noradrenaline, released by tyramine and lower body negative pressure (LBNP), on vascular post-synaptic alpha 1- and alpha 2-adrenoceptors have been compared in healthy volunteers. Intra-arterial (i.a.) infusions of noradrenaline and tyramine into the forearm were