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G9910

Sodium glycodeoxycholate

BioXtra, ≥97% (HPLC)

Synonym(s):

3α,12α-Dihydroxy-5β-cholan-24-oic acid N-(carboxymethyl)amide, Glycodeoxycholic acid sodium salt, Glycodesoxycholic acid, N-(3α,12α-Dihydroxy-24-oxocholan-24-yl)glycine

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About This Item

Empirical Formula (Hill Notation):
C26H42NNaO5
CAS Number:
16409-34-0
Molecular Weight:
471.61
NACRES:
NA.25
PubChem Substance ID:
24895386
UNSPSC Code:
12161900
EC Number:
240-455-4
MDL number:
MFCD00036742
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description

anionic

Quality Level

200

product line

BioXtra

assay

≥97% (HPLC)

mol wt

471.61 g/mol

impurities

≤0.0025% Phosphorus (P), ≤0.1% Insoluble matter

CMC

2.1 mM

solubility

H2O: 0.1 M, clear to slightly hazy, colorless to almost colorless

anion traces

chloride (Cl-): ≤1%, sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%, Ca: ≤0.011%, Cu: ≤0.0005%, Fe: ≤0.001%, K: ≤0.005%, NH4+: ≤0.05%, Pb: ≤0.001%, Zn: ≤0.003%

SMILES string

[Na].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(=O)NCC(O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C26H43NO5.Na.H/c1-15(4-9-23(30)27-14-24(31)32)19-7-8-20-18-6-5-16-12-17(28)10-11-25(16,2)21(18)13-22(29)26(19,20)3;;/h15-22,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);;/t15-,16-,17-,18+,19-,20+,21+,22+,25+,26-;;/m1../s1

InChI key

BMYWWGPEKRLDGW-ZXMGEDLUSA-N

General description

Sodium glycodeoxycholate is a bile salt that can be used to form biomimicking environments.

Application

Sodium glycodeoxycholate has been used in a study to develop more similar mimetic intestinal fluids to physiological fluids than those developed by mixed bile salt systems (MBS). It has also been used in a study to investigate Ca2+ buffering capability of bile salt micelles.

Biochem/physiol Actions

Induces apoptosis in hepatocytes; may induce DNA cleavage.

Other Notes

Bile Salt

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG6083
BCCG0654
BCCC1463
BCBZ2950
BCBW6151

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Articles

Probiotics and Human Health

Probiotics exhibit an inhibitory effect on pathogens, help prevent chronic intestinal inflammatory diseases or atopic syndromes, and support the immune system.

Hu-He Chen et al.
Guang pu xue yu guang pu fen xi = Guang pu, 30(3), 748-752 (2010-05-26)
In the present article, NaGDC was used to study the Ca(2+)-buffering capability of bile salt micelles. NaGDC is a naturally occurring bile salt which constitutes approximately 10 molar percent of bile salt composition in gallbladder. The authors selected glycine conjugated
Bile salt composition is secondary to bile salt concentration in determining hydrocortisone and progesterone solubility in intestinal mimetic fluids
Huda H Zughaid, et al.
International Journal of Pharmaceutics, 422, 7-7 (2012)
Elisabetta De Angelis et al.
Food & function, 8(4), 1599-1610 (2017-03-16)
Soy is an important component of the human diet thanks to its nutritional value and high protein content; however, it also represents a risk for allergenic consumers due to its potential to trigger adverse reactions in sensitized individuals. The putative
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Global Trade Item Number

SKUGTIN
G9910-1G04061833651353
G9910-250MG04061833651360
G9910-5G04061833651377