H128
(R)(−)-α-Methylhistamine dihydrochloride
≥98% (HPLC), Histamine receptor agonist, solid
Synonym(s):
(R)(−)-α-Methyl-1H-imidazole-4-ethanamine dihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C6H11N3 · 2HCl
CAS Number:
Molecular Weight:
198.09
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
(R)(−)-α-Methylhistamine dihydrochloride, solid, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
solid
optical activity
[α]22/D −4°, c = 0.8 in H2O(lit.)
storage condition
desiccated
color
white to off-white
solubility
H2O: soluble
SMILES string
Cl.Cl.C[C@@H](N)Cc1c[nH]cn1
InChI
1S/C6H11N3.2ClH/c1-5(7)2-6-3-8-4-9-6;;/h3-5H,2,7H2,1H3,(H,8,9);2*1H/t5-;;/m1../s1
InChI key
IZHCNQFUWDFPCW-ZJIMSODOSA-N
Gene Information
human ... HRH3(11255)
Application
(R)(−)-α-Methylhistamine dihydrochloride has been used as an agonist for the histamine H3 cell lines. It has also been used in the antagonist assay for the histamine H3 cell lines.
Biochem/physiol Actions
(R)(−)-α-Methylhistamine dihydrochloride is a potent, selective H3 histamine receptor agonist which crosses the blood-brain barrier. It can inhibit histamine synthesis and release.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Structure-activity relations of histamine analogs. XX. Absolute configuration and histamine-like activity of enantiomeric α-methyl histamines.
Gerhard, et al.
Archives of Pharmacal Research, 313, 709-709 (1980)
J M Arrang et al.
Nature, 327(6118), 117-123 (1987-05-14)
New drugs selective for histamine H3-receptors can be used to establish that these receptors are involved in the feedback control of histamine synthesis and release, and to demonstrate their distribution in the brain and peripheral tissues. These drugs provide new
Xu-Dong Wang et al.
Nature communications, 10(1), 3201-3201 (2019-07-22)
Pulmonary neuroendocrine (NE) cancer, including small cell lung cancer (SCLC), is a particularly aggressive malignancy. The lineage-specific transcription factors Achaete-scute homolog 1 (ASCL1), NEUROD1 and POU2F3 have been reported to identify the different subtypes of pulmonary NE cancers. Using a
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H128-5MG | 04061833664896 |
| H128-100MG | 04061832091129 |
| H128-25MG | 04061833664858 |