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Merck
CN

H3911

L-Histidine

Synonym(s):

(S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773

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About This Item

Empirical Formula (Hill Notation):
C6H9N3O2
CAS Number:
Molecular Weight:
155.15
UNSPSC Code:
12352209
NACRES:
NA.26
eCl@ss:
32160406
EC Number:
200-745-3
Beilstein/REAXYS Number:
84088
MDL number:
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biological source

non-animal source

Quality Level

assay

≥98.5%

form

crystalline powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, heavy metals, trace metals, residual solvents, tested

mp

282 °C (dec.) (lit.)

solubility

H2O: 50 mg/mL

suitability

suitable for manufacturing use

application(s)

pharmaceutical (small molecule)

foreign activity

cytotoxicity, tested

SMILES string

N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

InChI key

HNDVDQJCIGZPNO-YFKPBYRVSA-N

Gene Information

human ... CA1(759), CA2(760)

General description

Our SAFC® portfolio of high-quality raw materials for use in biopharmaceutical processing withstands strict quality control procedures plus the documentation and expertise to help our customers meet requirements as defined by the M-Clarity Program.

M-Clarity Program

Our comprehensive portfolio of upstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Trust us to deliver supply chain transparency and reliable sourcing around the globe, streamlining your product qualification with best-in-class regulatory support and service.
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.

Application

L-Histitidine is an essential amino acid. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.

Biochem/physiol Actions

Precursor of histamine by action of histidine decarboxylase.

Legal Information

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany


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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Shweta Singh et al.
Microbial cell factories, 7, 28-28 (2008-10-14)
The large-scale production of G-protein coupled receptors (GPCRs) for functional and structural studies remains a challenge. Recent successes have been made in the expression of a range of GPCRs using Pichia pastoris as an expression host. P. pastoris has a
Urszula Kosinska Eriksson et al.
Science (New York, N.Y.), 340(6138), 1346-1349 (2013-06-15)
Aquaporins are membrane channels that facilitate the flow of water across biological membranes. Two conserved regions are central for selective function: the dual asparagine-proline-alanine (NPA) aquaporin signature motif and the aromatic and arginine selectivity filter (SF). Here, we present the
Smriti Kala et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(16), 6022-6027 (2014-04-09)
The genome packaging reactions of tailed bacteriophages and herpes viruses require the activity of a terminase enzyme, which is comprised of large and small subunits. Phage genomes are replicated as linear concatemers composed of multiple copies of the genome joined



Global Trade Item Number

SKUGTIN
H3911-100G04061833794289
H3911-1KG04061833794296
H3911-10KG04061834415435
H3911-25KG04061834415442
H3911-A150X04061834180357
H3911-A150XCONF04061834180364