H5257
Hispidin
synthetic (organic), ≥98% (HPLC), protein kinase Cβ, solid
Synonym(s):
6-(3,4-dihydroxystyrl)-4-hydroxy-2-pyrone
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About This Item
Empirical Formula (Hill Notation):
C13H10O5
CAS Number:
Molecular Weight:
246.22
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
Hispidin, solid, ≥98% (HPLC)
biological source
synthetic (organic)
Quality Level
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
yellow to brown
mp
237.5-238.5 °C
solubility
DMSO: >10 mg/mL
storage temp.
−20°C
SMILES string
OC1=CC(/C=C/C(O2)=CC(O)=CC2=O)=CC=C1O
InChI
1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,14-16H/b3-1+
InChI key
SGJNQVTUYXCBKH-HNQUOIGGSA-N
Gene Information
human ... PRKACB(5567), PRKAR2B(5577), PRKCB(5579)
General description
Hispidin is a phenolic compound, that is obtained from a medicinal mushroom, Phellinus linteus.
Biochem/physiol Actions
Hispidin exhibits robust antioxidant, anticancer and antidiabetic properties. It has the ability to guard against peroxynitrite-mediated cytotoxicity, DNA damage and the development of hydroxyl radicals.
Potent inhibitor of protein kinase Cβ, cytotoxic for cancer cells.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
ppe
Eyeshields, Gloves, type N95 (US)
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Related Content
Wei Chen et al.
Chemico-biological interactions, 199(3), 137-142 (2012-07-24)
Oxidative stress plays an important role in the progression of many chronic diseases including cardiovascular diseases, diabetes, cancer and neurodegenerative disorders. One such mediator of oxidative stress is peroxynitrite, which is highly toxic to cultured neurons and astrocytes, and has
Guan-Jhong Huang et al.
Journal of agricultural and food chemistry, 59(10), 5702-5706 (2011-04-02)
The inhibitory activity from the isolated component of the fruiting body Phellinus merrillii (PM) was evaluated against α-glucosidase and lens aldose reductase from Sprague-Dawley male rats and compared to the quercetin as an aldose reductase inhibitor and acarbose as an
Li-feng Zan et al.
Chemical & pharmaceutical bulletin, 59(6), 770-772 (2011-06-02)
Two natural antioxidants, named inonotusin A (1) and B (2), were isolated from the methanolic extract of the fruit bodies of Inonotus hispidus, together with (E)-4-(3,4-dihydroxyphenyl)but-3-en-2-one (3), hispidin (4) and 3,4-dihydroxybenzaldehyde (5). Their structures were identified by means of extensive
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H5257-5MG | 04061833798027 |