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H7250

Histamine dihydrochloride

Name: Histamine dihydrochloride
Brand: SIGMA

≥99% (TLC), powder, endogenous histamine receptor agonist

Synonym(s):

2-(4-Imidazolyl)ethylamine dihydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₅H₉N₃ · 2HCl

CAS Number:

56-92-8

Molecular Weight:

184.07

EC Number:

200-298-4

NACRES:

NA.77

PubChem Substance ID:

24277777

eCl@ss:

32160406

UNSPSC Code:

12352116

MDL number:

MFCD00012703

Beilstein/REAXYS Number:

3624116

Assay:

≥99% (TLC)

Form:

powder

Quality level:

200

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Properties

Product Name

Histamine dihydrochloride, ≥99% (TLC), powder

Quality Level

200

assay

≥99% (TLC)

form

powder

color

white to off-white

mp

249-252 °C (lit.)

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].NCCc1c[nH]cn1

InChI

1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H

InChI key

PPZMYIBUHIPZOS-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269), HRH2(3274)

Description

General description

Histamine dihydrochloride is a derivative of histamine. It prevents the formation of ROS (reactive oxygen species), which inhibits the activation of T cells and natural killer cells. Histamine dihydrochloride is implicated in tumor cell apoptosis. It prevents the relapse of acute myeloid leukemia in patients.

Application

Histamine dihydrochloride has been used:

as a orthograde cotransmitter in producing excitatory postsynaptic potential (EPSP)
to determine its level in fish using HPLC (high performance liquid chromatography)
to assess the tracheal response to antigens in guinea-pigs

Biochem/physiol Actions

Endogenous H₁ and H₂ histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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pictograms

GHS08,GHS07

signalword

Danger

hcodes

H315,H317,H319,H334,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Articles

DISCOVER Bioactive Small Molecules for Neuroscience

Nitric oxide as an orthograde cotransmitter at central synapses of Aplysia: responses of isolated neurons in culture

Jacklet JW and Koh HY

American Zoologist, 41(2), 282-291 (2001)

Histamine H4 receptor: a Novel Drug Target For Immunoregulation and Inflammation (2013)

Determination of some quality criteria of cold storaged marinated anchovy under vacuum and modified atmosphere conditions

Guncsen U, et al.

Turkish Journal of Fisheries and Aquatic Sciences, 11(2), 282-291 (2011)

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Global Trade Item Number

SKU	GTIN
H7250-10MG	04061835253289
H7250-5G	04061835253302
H7250-10G	04061835253272
H7250-25G	04061835253296