H7283
Heat Shock Protein 70 human
recombinant, expressed in E. coli, buffered aqueous solution, ≥90% (SDS-PAGE)
Synonym(s):
HSP 70
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Form:
buffered aqueous solution
Assay:
≥90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
biological source
human
Quality Level
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
buffered aqueous solution
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... HSPA8(3312)
Application
Heat shock protein 70 human has been used as a control for checking antibody reactivity.
Biochem/physiol Actions
HSPA8 (heat shock 70kDa protein 8) is a human cytoplasmic chaperone which is involved in protein folding, protein aggregation prevention and protein transport. During nutrient stress, it participates in antigen transport to regulate MHC (major histocompatibility) class II presentation. It is upregulated in cancer cells and is involved in protein homeostasis, leading to cancer cell growth and survival.
Physical form
Solution in 2.7 mM KCl, 1.5 mM KH2PO4, 137 mM NaCl, and 8.1 mM Na2HPO4.
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Huaqun Zhang et al.
Structure (London, England : 1993), 23(3), 472-482 (2015-02-17)
The ubiquitin ligase CHIP plays an important role in cytosolic protein quality control by ubiquitinating proteins chaperoned by Hsp70/Hsc70 and Hsp90, thereby targeting such substrate proteins for degradation. We present a 2.91 Å resolution structure of the tetratricopeptide repeat (TPR)
Sarah N Deffit et al.
Molecular immunology, 68(2 Pt A), 85-88 (2015-05-09)
Cells rely on multiple intracellular trafficking pathways to capture antigens for proteolysis. The resulting peptides bind to MHC class II molecules to promote CD4(+) T cell recognition. Endocytosis enhances the capture of extracellular and cell surface bound antigens for processing
Bing Zhou et al.
Journal of virology, 82(14), 6962-6971 (2008-05-02)
Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of SARS, an emerging disease characterized by atypical pneumonia. Using a yeast two-hybrid screen with the nucleocapsid (N) protein of SARS-CoV as a bait, the C terminus (amino acids 251
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H7283-50UG | 04061838031334 |