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H9039

Hemin

Name: Hemin
Brand: SIGMA

from bovine, ≥90%

Synonym(s):

Chloro(protoporphyrinato)iron(III), Chlorohemin, Chloroprotoporphyrin IX iron(III), Ferriprotoporphyrin IX chloride, Hemin(chloride)

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About This Item

Empirical Formula (Hill Notation):

C₃₄H₃₂ClFeN₄O₄

CAS Number:

16009-13-5

Molecular Weight:

651.94

UNSPSC Code:

12352202

NACRES:

NA.61

PubChem Substance ID:

329815257

EC Number:

240-140-1

Beilstein/REAXYS Number:

5229914

MDL number:

MFCD00010726

Form:

powder

Assay:

≥90%

Biological source:

bovine

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Properties

biological source

bovine

Quality Level

200

assay

≥90%

form

powder

technique(s)

toxicology assay: suitable

solubility

1.4 M NH₄OH: soluble 25 mg/mL

storage temp.

2-8°C

SMILES string

Cc1c(CCC(O)=O)c2cc3c(CCC(O)=O)c(C)c4cc5nc(cc6c(C)c(C=C)c(cc1n2)n6[Fe](Cl)n34)c(C=C)c5C

InChI

1S/C34H34N4O4.ClH.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;;/h7-8,13-16H,1-2,9-12H2,3-6H3,(H4,35,36,37,38,39,40,41,42);1H;/q;;+3/p-3/b25-13-,26-13-,27-14-,28-15-,29-14-,30-15-,31-16-,32-16-;;

InChI key

BTIJJDXEELBZFS-HXFTUNQESA-K

Description

General description

Heme is a small molecule present either free or bound to hemoglobin in the bloodstream of mammals. This is an alternative source of iron within the host that contains a porphyrin ring containing a Fe²⁺ ion called hemin.

Application

Hemin was used to study conjugation, characterization and toxicity of lipophosphoglycan-polyacrylic acid conjugate for vaccination against leishmaniasis.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Conjugation, characterization and toxicity of lipophosphoglycan-polyacrylic acid conjugate for vaccination against leishmaniasis.

Murat Topuzogullari et al.

Journal of biomedical science, 20, 35-35 (2013-06-05)

Research on the conjugates of synthetic polyelectrolytes with antigenic molecules, such as proteins, peptides, or carbohydrates, is an attractive area due to their highly immunogenic character in comparison to classical adjuvants. For example, polyacrylic acid (PAA) is a weak polyelectrolyte

Post-embryonic development in Caenorhabditis elegans.

D L Riddle

International journal for parasitology, 17(1), 223-231 (1987-02-01)

The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans.

Rodgoun Attarian et al.

mBio, 9(6) (2018-12-06)

The acquisition of iron and the maintenance of iron homeostasis are important aspects of virulence for the pathogenic fungus Cryptococcus neoformans In this study, we characterized the role of the monothiol glutaredoxin Grx4 in iron homeostasis and virulence in C.

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Global Trade Item Number

SKU	GTIN
H9039-1G	04061835506354
H9039-100G	04061833811917
H9039-10G	04061835512638