I1771
Interleukin-13 human
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
IL-13
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About This Item
biological source
human
Quality Level
recombinant
expressed in E. coli
assay
≥97% (SDS-PAGE)
form
lyophilized powder
potency
<10.000 ng/mL ED50
mol wt
12 kDa
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
color
white
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IL13(3596)
Biochem/physiol Actions
IL-13 is known to be overexpressed in glioblastoma tumors and cell lines. Elevated IL-13 expression is also observed in parasitic infections. It stimulates fibrosis in many infectious diseases, and acts as a profibrogenic factor.
Interleukin-13 is a pleiotropic cytokine produced by activated Th2 cells in the mouse and human. IL-13 is secreted mainly as an unglycosylated protein of 132 amino acids with a molecular weight of 10,000 daltons. A 4.3kb DNA fragment of the mouse IL-13 gene was sequenced and occurs as a single copy mapping a chromosome 11. In the human, a 4.6 kb DNA segment of the IL-13 gene occurs as a single copy and maps to chromosome 5. IL-13 induces B cell proliferation and also induces IgE switching. The proliferative activity of human and mouse IL-13 products are tested in culture using the human erythroleukemic cell line TF-1.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 250 μg BSA.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
低风险生物材料
常规特殊物品
含少量动物源组分生物产品
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Articles
Interleukins, released from leukocytes, include IL-1β playing crucial roles in inflammation, immune responses, and anti-tumor immunity.
Related Content
An IL-13 promoter polymorphism associated with liver fibrosis in patients with Schistosoma japonicum.
Long X et al
PLoS ONE, 10(8), e0135360-e0135360 (2015)
Ji-Yun Lee et al.
Journal of immunology (Baltimore, Md. : 1950), 194(12), 5990-5998 (2015-05-15)
Mucin overproduction is a hallmark of otitis media (OM). Streptococcus pneumoniae is one of the most common bacterial pathogens causing OM. Mucin MUC5AC plays an important role in mucociliary clearance of bacterial pathogens. However, if uncontrolled, excessive mucus contributes significantly
Yan Deng et al.
PloS one, 10(2), e0116682-e0116682 (2015-02-07)
Interleukin-13 (IL-13) is a potent pleiotropic cytokine that is produced by activated CD4 T cells. This study was undertaken to determine the relationship between two IL-13 gene single nucleotide polymorphisms (SNP rs1800925 and SNP rs20541) and the incidence of hepatitis
Global Trade Item Number
| SKU | GTIN |
|---|---|
| I1771-10UG | 04061833848081 |