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About This Item
Conjugate:
unconjugated
Clone:
K36AC10, monoclonal
Application:
DB, IHC (p), RIA
Citations:
125
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
K36AC10, monoclonal
contains
15 mM sodium azide
species reactivity
feline, human, rat, horse, rabbit, guinea pig, bovine, monkey, sheep, canine, pig
technique(s)
dot blot: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using human or animal pancreas, radioimmunoassay: suitable
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... INS(3630)
General description
The antibody reacts specifically against insulin by RIA and immunocytochemistry. It exhibits cross-reactivity with human proinsulin. The antibody binds to insulin with an affinity constant of 8.8 × 109 M-1 in RIA.
The insulin gene is mapped to human chromosome 11p15.5.
Application
Monoclonal Anti-Insulin antibody produced in mouse has been used in immunoblotting assay and ELISA.
Monoclonal Anti-Insulin antibody produced in mouse was used in ELISA-based protein pin array assay to study the interactions between human αB crystalline and insulin. It was used for flow cytometric analysis of rat white blood cells and mast cells.
Biochem/physiol Actions
Insulin is a major regulatory hormone important in the metabolic processes, transport of glucose, amino acids and certain ions. It is also involved in the synthesis of nucleic acids and proteins. The biological effects of insulin are mediated by insulin receptor and it integrates multiple major signaling pathways.
Insulin is a major regulatory hormone important in the metabolic processes, transport of glucose, amino acids and certain ions. It is also involved in the synthesis of nucleic acids and proteins. The biological effects of insulin are mediated by insulin receptor and it integrates multiple major signaling pathways. Abnormal insulin secretion or function leads to diabetes mellitus, obesity and other carbohydrate metabolism disorders. Insulin is known to stimulate cell division.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
Regulatory Information
常规特殊物品
动物来源生物产品
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Related Content
Sandra K Szlapinski et al.
The Journal of physiology, 597(16), 4237-4250 (2019-06-18)
Pancreatic β-cell dysfunction is hypothesized to be the significant determinant of gestational diabetes pathogenesis, however pancreatic samples from patients are scarce. This study reports a novel mouse model of gestational glucose intolerance in pregnancy, originating from previous nutrition restriction in
Lechago J and Shah I
Atlas of Diagnostic Immunochemistry null
Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells.
Wang F, et al.
Diabetes, 50(11), 2514-2520 (2001)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| I2018-.2ML | 04061833848258 |
| I2018-100UL | 04061838031402 |