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I4909

Ifosfamide

Name: Ifosfamide
Brand: SIGMA

≥98%

Synonym(s):

Ifex, N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-oxide

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About This Item

Empirical Formula (Hill Notation):

C₇H₁₅Cl₂N₂O₂P

CAS Number:

3778-73-2

Molecular Weight:

261.09

EC Number:

223-237-3

MDL number:

MFCD00057374

NACRES:

NA.25

PubChem Substance ID:

329815378

UNSPSC Code:

41116107

Assay:

≥98%

Quality level:

200

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Properties

Quality Level

200

assay

≥98%

shipped in

wet ice

storage temp.

2-8°C

SMILES string

ClCCNP1(=O)OCCCN1CCCl

InChI

1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)

InChI key

HOMGKSMUEGBAAB-UHFFFAOYSA-N

Description

Application

Ewing sarcoma of the pancreas: a pediatric case report and narrative literature review: This study explores the effectiveness of Ifosfamide in the treatment of rare pediatric Ewing sarcoma of the pancreas, providing valuable insights into the chemotherapeutic management of rare cancers (Liu et al., 2024).

Prognostic value of hemogram parameters in osteosarcoma: The French OS2006 experience: Highlights the role of Ifosfamide in osteosarcoma treatment as part of a clinical trial, evaluating its impact on survival rates and treatment outcomes (Bastard et al., 2024).

Case report: Characteristics and nature of primary cardiac synovial sarcoma: Discusses the utilization of Ifosfamide in managing primary cardiac synovial sarcoma, with an emphasis on its pharmacodynamics and therapeutic efficacy (Kawasaki et al., 2024).

Dedifferentiated liposarcoma of the spermatic cord: Examines Ifosfamide′s mechanism of action in treating dedifferentiated liposarcoma, contributing to the broader understanding of its application in sarcoma therapy (Panther et al., 2024).

A Rare Case of Extranodal Natural Killer/T-cell Lymphoma, Nasal Type Associated With Hemophagocytic Lymphohistiocytosis in a Patient With Recurrent Sinusitis: This article details the clinical use of Ifosfamide in treating aggressive lymphoma, underscoring its role in complex cases where standard treatments may not suffice (Christensen et al., 2024).

Biochem/physiol Actions

Ifosfamide is a nitrogen mustard compound that is a structural isomer of cyclophosphamide. Ifosfamide is a prodrug that must be transformed by cytochrome P450 to the biologically active component. It is used as an antineoplastic agent in cancer chemotherapy, but ifosfamide is more likely to cause renal toxicity than cyclophosphamide.