I7016
H-7 dihydrochloride
≥98% (HPLC)
Synonym(s):
1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride, Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C14H17N3O2S · 2HCl
CAS Number:
Molecular Weight:
364.29
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5840763
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
H2O: 20 mg/mL
storage temp.
2-8°C
SMILES string
Cl.Cl.CC1CNCCN1S(=O)(=O)c2cccc3cnccc23
InChI
1S/C14H17N3O2S.2ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14;;/h2-6,10-11,16H,7-9H2,1H3;2*1H
InChI key
OARGPFMFRLLKPF-UHFFFAOYSA-N
Gene Information
human ... PRKCA(5578), PRKCB(5579), PRKCD(5580), PRKCE(5581), PRKCG(5582), PRKCH(5583), PRKCI(5584)
General description
H-7 dihydrochloride blocks human immunodeficiency virus (HIV-1) replication in MOLT-4 (clone No. 8) cell line. It increases the secretion of interleukin 1β (IL-1β).
Application
H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.
Biochem/physiol Actions
Inhibitor of cyclic nucleotide dependent protein kinase (PKA) and protein kinase C.
Disclaimer
Light sensitive
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Mechanism of inhibitory effect of glycyrrhizin on replication of human immunodeficiency virus (HIV)
Ito M, et al.
Antiviral Research, 10(6), 289-298 (1988)
A new dimension in retrograde flow: centripetal movement of engulfed particles
Caspi A, et al.
Biophysical Journal, 81(4), 1990-2000 (2001)
Molecular diversity of cell-matrix adhesions
Zamir E, et al.
Journal of Cell Science, 112(11), 1655-1669 (1999)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| I7016-25MG | 04061832434063 |
| I7016-100MG | 04061832271927 |
| I7016-5MG | 04061833857991 |