I7776
Anti-Interleukin-4 antibody produced in goat
affinity isolated antibody, lyophilized powder
Synonym(s):
Anti-IL-4
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
Neutral, WB
Citations:
16
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
mouse
technique(s)
neutralization: suitable, western blot: suitable
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Il4(16189)
General description
The antibody will neutralize the biological activity of recombinant mouse IL-4, but not recombinant human IL-4. It shows <5% cross-reactivity with recombinant rat IL-4, and shows no cross-reactivity with recombinant human IL-4.
Immunogen
recombinant mouse IL-4.
Biochem/physiol Actions
Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signaling stimulated by IL-4 leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages.
Physical form
Lyophilized from 0.2 μm filtered solution in phosphate buffered saline..
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Related Content
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| I7776-.1MG | 04061832714769 |